Blue Light (400−495 nm)

Name	AC	CK
Blue Light Toxicity	27	94
Sleep Disorders	5	50
Retinal Degeneration: Light-Induced	17	48
Macular Degeneration	18	32
Eye Damage	18	25
Oxidative Stress	12	22
Circadian Dysregulation	3	21
Bipolar Disorder	2	20
Insomnia	2	20
Depression	3	14
Aging Skin	2	11
Glaucoma	2	11
Photooxidative Stress	8	11
Delayed Sleep Phase Disorder	1	10
Depression: Postpartum	1	10
Hormone Imbalances: Low Melatonin	1	10
Seasonal Affective Disorder	1	10
Smart Phone Addiction	1	10
DNA damage	4	4
Inflammation	2	4
Dry Eye Syndromes	2	3
Melanoma: Uveal	2	3
Male Reproductive Development Abnormalities	1	2
Retinal Diseases	1	2
Cataract	1	1
Lipid Peroxidation	1	1
Mitochondrial Diseases	1	1
Skin Diseases	1	1
Skin Diseases: Photo-Aging	1	1

Name	AC	CK
Oxidant	1	10
Apoptotic	3	3
Inflammatory	1	2
Proliferative	1	2

[+]

Acute exposure to evening blue‐enriched light impacts on human sleep.Sep 30, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Sleep Res. 2013 Oct ;22(5):573-80. Epub 2013 Mar 20. PMID: 23509952

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Diseases : Sleep Disorders

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Amber lenses could be used to block blue light and improve sleep.Nov 30, 2009

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Pubmed Data : Chronobiol Int. 2009 Dec ;26(8):1602-12. PMID: 20030543

Article Published Date : Nov 30, 2009

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation

Therapeutic Actions : Amber Lenses

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Amber lenses represent a safe, affordable, and easily implemented therapeutic intervention for insomnia symptoms.Dec 31, 2017

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Pubmed Data : J Psychiatr Res. 2018 Jan ;96:196-202. Epub 2017 Oct 21. PMID: 29101797

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Diseases : Insomnia

Therapeutic Actions : Amber Lenses, Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blocking short-wavelength light in the evening hours may be beneficial for patients suffering from insomnia.Dec 31, 2019

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Pubmed Data : Chronobiol Int. 2020 02 ;37(2):248-259. Epub 2019 Nov 22. PMID: 31752544

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Diseases : Blue Light Toxicity, Insomnia

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue blocking glasses are effective and feasible as add‐on treatment for bipolar mania.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bipolar Disord. 2016 05 ;18(3):221-32. PMID: 27226262

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Bipolar Disorder

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light-filtering toric intraocular lenses produced a significantly greater reduction in glare disability than the UV-only filtered lenses. Apr 30, 2012

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Pubmed Data : J Cataract Refract Surg. 2012 May ;38(5):816-22. PMID: 22520305

Article Published Date : Apr 30, 2012

Study Type : Human Study

Additional Links

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue-blocking glasses may be useful as an adjunctive treatment for circadian rhythm issues in patients with bipolar disorder.Apr 09, 2020

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Pubmed Data : Bipolar Disord. 2020 Apr 10. Epub 2020 Apr 10. PMID: 32276301

Article Published Date : Apr 09, 2020

Study Type : Human Study

Additional Links

Diseases : Bipolar Disorder, Blue Light Toxicity

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue-light filtering spectacle lenses can partially filter high-energy short-wavelength light without substantially degrading visual performance.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(1):e0169114. Epub 2017 Jan 3. PMID: 28045969

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue-violet light irradiation dose dependently decreases carotenoids in human skin.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2015 ;2015:579675. Epub 2015 Feb 9. PMID: 25741404

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Diseases : Blue Light Toxicity

Anti Therapeutic Actions : Blue Light (400−495 nm)

Adverse Pharmacological Actions : Oxidant

[+]

Circadian phase, dynamics of subjective sleepiness and sensitivity to blue light in young adults complaining of a delayed sleep schedule.May 31, 2017

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Pubmed Data : Sleep Med. 2017 Jun ;34:148-155. Epub 2017 Apr 4. PMID: 28522084

Article Published Date : May 31, 2017

Study Type : Human Study

Additional Links

Diseases : Sleep Disorders

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Effect of blue light-reducing eye glasses on critical flicker frequency.Feb 28, 2015

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Pubmed Data : Asia Pac J Ophthalmol (Phila). 2015 Mar-Apr;4(2):80-5. PMID: 26065349

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Exposure to blue light during lunch break: effects on autonomic arousal and behavioral alertness.Jul 10, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Physiol Anthropol. 2017 Jul 11 ;36(1):30. Epub 2017 Jul 11. PMID: 28697776

Article Published Date : Jul 10, 2017

Study Type : Human Study

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Exposure to blue wavelength light modulates anterior cingulate cortex activation in response to 'uncertain' versus 'certain' anticipation of positive stimuli.Mar 10, 2016

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Pubmed Data : Neurosci Lett. 2016 Mar 11 ;616:5-10. Epub 2016 Jan 22. PMID: 26806862

Article Published Date : Mar 10, 2016

Study Type : Human Study

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

High-energy blue light from visual display terminals can be a risk factor in the ocular surface damage.Jun 10, 2018

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Pubmed Data : Zhonghua Yan Ke Za Zhi. 2018 Jun 11 ;54(6):426-431. PMID: 29895116

Article Published Date : Jun 10, 2018

Study Type : Human Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

L. paracasei KW3110 suppressed blue light-induced retinal pigment epithelial cell death.Aug 08, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Aug 9 ;10(8). Epub 2018 Aug 9. PMID: 30096952

Article Published Date : Aug 08, 2018

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Lactobacillus paracasei

Diseases : Blue Light Toxicity

Pharmacological Actions : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Morning and evening blue-enriched light exposure alters metabolic function in normal weight adults.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(5):e0155601. Epub 2016 May 18. PMID: 27191727

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

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Pubmed Data : Chronobiol Int. 2016 ;33(1):134-9. Epub 2016 Jan 5. PMID: 26730983

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin

Additional Keywords : Light Pollution

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Pigmentation effects of blue light irradiation on skin and how to protect against them.Jul 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cosmet Sci. 2020 Aug ;42(4):399-406. PMID: 32478879

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Algae, Vitamin B-3 (Niacin)

Diseases : Aging Skin, Blue Light Toxicity

Therapeutic Actions : Placebo Effect

Pharmacological Actions : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Pupillary responses to high-irradiance blue light correlate with glaucoma severity.Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ophthalmology. 2015 Sep ;122(9):1777-85. PMID: 26299721

Article Published Date : Aug 31, 2015

Study Type : Human Study

Additional Links

Diseases : Glaucoma

Additional Keywords : Increased Risk

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Sleep quality decreases with smartphone usage among people who do not usually use their smartphones before going to sleep and do not have any sleep problems.Mar 31, 2022

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Pubmed Data : J Cosmet Dermatol. 2022 Apr ;21(4):1656-1665. Epub 2021 Jun 18. PMID: 34062052

Article Published Date : Mar 31, 2022

Study Type : Human Study

Additional Links

Diseases : Blue Light Toxicity, Sleep Disorders, Smart Phone Addiction

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Suppression of vagal cardiac modulation by blue light in healthy subjects.Oct 04, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Physiol Anthropol. 2016 Oct 5 ;35(1):24. Epub 2016 Oct 5. PMID: 27716445

Article Published Date : Oct 04, 2016

Study Type : Human Study

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

The use of blue light smartphones was associated with significantly decreased sleepiness and confusion-bewilderment.Dec 31, 2016

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Pubmed Data : J Psychiatr Res. 2017 04 ;87:61-70. Epub 2016 Dec 12. PMID: 28017916

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Sleep Disorders

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

These results further emphasize the interaction of light exposure with depression.Feb 28, 2018

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Pubmed Data : Acta Psychiatr Scand. 2018 Mar ;137(3):231-240. Epub 2018 Jan 15. PMID: 29336011

Article Published Date : Feb 28, 2018

Study Type : Human Study

Additional Links

Diseases : Depression

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

This brings important concerns with regard to blue-enriched light therapy lamps used to treat SAD symptoms and other disorders.Jan 14, 2011

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15 ;35(1):227-31. Epub 2010 Nov 20. PMID: 21094670

Article Published Date : Jan 14, 2011

Study Type : Human Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced, Seasonal Affective Disorder

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Use of modified spectacles and light bulbs to block blue light at night may prevent postpartum depression.Jul 31, 2009

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Pubmed Data : Med Hypotheses. 2009 Aug ;73(2):251-3. Epub 2009 Mar 28. PMID: 19329259

Article Published Date : Jul 31, 2009

Study Type : Human Study

Additional Links

Diseases : Depression: Postpartum

Therapeutic Actions : Blue Light Blocking

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Risk Reduction

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Chronobiol Int. 2016 ;33(8):1037-44. Epub 2016 Jun 20. PMID: 27322730

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Delayed Sleep Phase Disorder, Sleep Disorders

Therapeutic Actions : Amber Lenses, Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Filtering blue light reduces light-induced oxidative stress, senescence and accumulation of extracellular matrix proteins in retinal cells.Dec 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):e87-97. Epub 2011 Aug 18. PMID: 21668780

Article Published Date : Dec 31, 2011

Study Type : Human In Vitro

Additional Links

Diseases : Macular Degeneration, Oxidative Stress, Retinal Degeneration: Light-Induced

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

A case report of damage to the macula associated with LED-derived blue laser exposure.Apr 23, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Ophthalmol. 2017 Apr 24 ;17(1):49. Epub 2017 Apr 24. PMID: 28438153

Article Published Date : Apr 23, 2017

Study Type : Human: Case Report

Additional Links

Diseases : Eye Damage, Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Protective effect of Ribes nigrum extract against blue light-induced retinal degeneration.Apr 24, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2022 Apr 25 ;11(5). Epub 2022 Apr 25. PMID: 35624696

Article Published Date : Apr 24, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Blue Light Toxicity, Macular Degeneration

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Wolfberry water extract attenuates blue light-emitting diode damage to ARPE-19 cells and mouse retina.Apr 30, 2023

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Pubmed Data : J Food Sci. 2023 May ;88(5):2229-2245. Epub 2023 Apr 6. PMID: 37025094

Article Published Date : Apr 30, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Goji

Diseases : Blue Light Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen.Oct 27, 2023

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Pubmed Data : Free Radic Res. 2023 Oct 28:1-14. Epub 2023 Oct 28. PMID: 37897411

Article Published Date : Oct 27, 2023

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Blue Light Toxicity, Eye Damage, Macular Degeneration

Pharmacological Actions : Antioxidants, Cytoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light exposure led to a statistically significant increase in proliferation for cell lines derived from intraocular tumors.Apr 06, 2009

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2009 Apr 7 ;28:48. Epub 2009 Apr 7. PMID: 19351402

Article Published Date : Apr 06, 2009

Study Type : Animal Study

Additional Links

Diseases : Melanoma: Uveal

Anti Therapeutic Actions : Blue Light (400−495 nm)

Adverse Pharmacological Actions : Proliferative

[+]

Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats.Apr 17, 2018

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Pubmed Data : Photochem Photobiol Sci. 2018 Apr 18 ;17(4):386-394. PMID: 29404551

Article Published Date : Apr 17, 2018

Study Type : Animal Study

Additional Links

Diseases : Depression

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light induced A2E oxidation in rat eyes.Oct 31, 2010

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Pubmed Data : Photochem Photobiol Sci. 2010 Nov ;9(11):1505-12. Epub 2010 Oct 5. PMID: 20922251

Article Published Date : Oct 31, 2010

Study Type : Animal Study

Additional Links

Diseases : Macular Degeneration, Photooxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light reduces melanopsin expression in intrinsically photoreceptive retinal ganglion cells and damages the inner retina.Jan 02, 2022

Click here to read the entire abstract

Pubmed Data : Invest Ophthalmol Vis Sci. 2022 Jan 3 ;63(1):26. PMID: 35060997

Article Published Date : Jan 02, 2022

Study Type : Animal Study

Additional Links

Diseases : Blue Light Toxicity, Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue-light filtering alters angiogenic signaling in human retinal pigmented epithelial cells culture modelNov 01, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Ophthalmol. 2017 Nov 2 ;17(1):198. Epub 2017 Nov 2. PMID: 29096624

Article Published Date : Nov 01, 2017

Study Type : Animal Study

Additional Links

Diseases : Macular Degeneration, Oxidative Stress

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Cynaroside protects the blue light-induced retinal degeneration through alleviating apoptosis and inducing autophagy in vitro and in vivo.Jul 14, 2021

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Pubmed Data : Phytomedicine. 2021 Jul 15 ;88:153604. Epub 2021 May 24. PMID: 34130054

Article Published Date : Jul 14, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Blue Light Toxicity, Photooxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Daytime exposure to blue light alters cardiovascular circadian rhythms, electrolyte excretion and melatonin production.Mar 13, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pathophysiology. 2022 Mar 14 ;29(1):118-133. Epub 2022 Mar 14. PMID: 35366294

Article Published Date : Mar 13, 2022

Study Type : Animal Study

Additional Links

Diseases : Blue Light Toxicity

Additional Keywords : Circadian Rhythm

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice.Jul 20, 2018

Click here to read the entire abstract

Pubmed Data : Exp Eye Res. 2018 Jul 21 ;177:1-11. Epub 2018 Jul 21. PMID: 30040948

Article Published Date : Jul 20, 2018

Study Type : Animal Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Light colour and intensity alters reproductive/seasonal responses in Japanese quail.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : Physiol Behav. 2015 Aug 1 ;147:163-8. Epub 2015 Apr 23. PMID: 25912834

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Male Reproductive Development Abnormalities

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Light regulates the expression of the BDNF/TrkB system in the adult zebrafish retina.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Microsc Res Tech. 2013 Jan ;76(1):42-9. Epub 2012 Oct 16. PMID: 23070877

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors.Mar 05, 2023

Click here to read the entire abstract

Pubmed Data : Food Funct. 2023 Mar 6 ;14(5):2313-2325. Epub 2023 Mar 6. PMID: 36779860

Article Published Date : Mar 05, 2023

Study Type : Animal Study

Additional Links

Substances : Black Tea

Diseases : Blue Light Toxicity, Depression

Pharmacological Actions : Antidepressive Agents

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Low-luminance blue light-enhanced phototoxicity in A2E-laden RPE cell cultures.Apr 10, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2019 Apr 11 ;20(7). Epub 2019 Apr 11. PMID: 30979028

Article Published Date : Apr 10, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Blue Light Toxicity, Retinal Diseases

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Molecular mechanism of the protective effect of lutein against retinal damage induced by blue-light in rats.Oct 31, 2010

Click here to read the entire abstract

Pubmed Data : Wei Sheng Yan Jiu. 2010 Nov ;39(6):689-92. PMID: 21351632

Article Published Date : Oct 31, 2010

Study Type : Animal Study

Additional Links

Substances : Lutein

Diseases : Photooxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

N-acetylcysteine protected against blue LED light-induced retinal damage in a dose-dependent manner.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2017 ;40(8):1219-1225. PMID: 28769003

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Oxidative Stress, Retinal Degeneration: Light-Induced

Pharmacological Actions : Antioxidants

Additional Keywords : Dose Response

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Neuroglobin is a potential biological marker of retinal damage induced by LED light.Jun 12, 2014

Click here to read the entire abstract

Pubmed Data : Neuroscience. 2014 Jun 13 ;270:158-67. Epub 2014 Apr 18. PMID: 24747803

Article Published Date : Jun 12, 2014

Study Type : Animal Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm), LED Lighting

[+]

Overexposure to blue light with short wavelengths can induce oxidative damage and apoptosis to the cornea.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(8):e0161041. Epub 2016 Aug 12. PMID: 27517861

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Dry Eye Syndromes, Eye Damage, Inflammation

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Photo-oxidative blue-light stimulation in retinal pigment epithelium cells promotes exosome secretion and increases the activity of the NLRP3 inflammasome.Sep 09, 2018

Click here to read the entire abstract

Pubmed Data : Curr Eye Res. 2018 Sep 10:1-9. Epub 2018 Sep 10. PMID: 30198786

Article Published Date : Sep 09, 2018

Study Type : Animal Study

Additional Links

Diseases : Macular Degeneration

Additional Keywords : Exosomes

Anti Therapeutic Actions : Blue Light (400−495 nm)

Adverse Pharmacological Actions : Inflammatory

[+]

Phototoxicity of LEDs on the retina is characterized by a strong damage of photoreceptors and by the induction of necrosis.Jun 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Free Radic Biol Med. 2015 Jul ;84:373-384. Epub 2015 Apr 8. PMID: 25863264

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Eye Damage, Oxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm), LED Lighting

[+]

Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Nutr Res. 2016 Dec ;36(12):1402-1414. Epub 2016 Nov 18. PMID: 27993192

Article Published Date : Nov 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Eye Damage, Macular Degeneration

Pharmacological Actions : Anti-Apoptotic

Additional Keywords : Phytotherapy, Plant Extracts

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Protective effect of Prunella vulgaris var. L extract against blue light induced damages in ARPE-19 cells and mouse retina.Dec 04, 2019

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31811921

Article Published Date : Dec 04, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Prunella vulgaris

Diseases : Blue Light Toxicity, Macular Degeneration

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Rutin intake mitigates the injury of blue light irradiation by altering aging rates of mortality in Drosophila model.Sep 03, 2023

Click here to read the entire abstract

Pubmed Data : Photochem Photobiol. 2023 Sep 4. Epub 2023 Sep 4. PMID: 37665025

Article Published Date : Sep 03, 2023

Study Type : Insect Study

Additional Links

Substances : Rutin

Diseases : Blue Light Toxicity

Pharmacological Actions : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

The blockade of blue plus additional visible wavelengths of light was most effective in protecting the retina from light-induced damage. Jul 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Exp Ophthalmol. 2014 Aug ;42(6):555-63. Epub 2013 Dec 4. PMID: 24304494

Article Published Date : Jul 31, 2014

Study Type : Animal Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Therapeutic Actions : Blue Light Blocking

Pharmacological Actions : Anti-Apoptotic

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance.Dec 16, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neuroscience. 2016 Dec 17 ;339:296-307. Epub 2016 Oct 14. PMID: 27751961

Article Published Date : Dec 16, 2016

Study Type : Animal Study

Additional Links

Diseases : Macular Degeneration, Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm), LED Lighting

[+]

The potential damage caused by blue light can be palliated.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2018 ;13(3):e0194218. Epub 2018 Mar 15. PMID: 29543853

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

These results raise questions about adverse effects on the retina from chronic exposure to LED light compared with other light sources that have less blue light.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2014 Mar ;122(3):269-76. Epub 2013 Dec 20. PMID: 24362357

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Diseases : Oxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm), LED Lighting

[+]

These results suggest that L. paracasei KW3110 may have a preventive effect against degrative retinal diseases.Dec 14, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Dec 15 ;10(12). Epub 2018 Dec 15. PMID: 30558320

Article Published Date : Dec 14, 2018

Study Type : Animal Study

Additional Links

Substances : Lactobacillus paracasei

Diseases : Blue Light Toxicity, Inflammation, Macular Degeneration, Retinal Degeneration: Light-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Visual functional effects of constant blue light in a retinal degenerate rat model.Apr 30, 2007

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Photochem Photobiol. 2007 May-Jun;83(3):759-65. PMID: 17115798

Article Published Date : Apr 30, 2007

Study Type : Animal Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

A review of the effects and safety of the blue light on retinal cells.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Zhonghua Yan Ke Za Zhi. 2015 Jan ;51(1):65-9. PMID: 25877712

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Astaxanthin exerted a dose-dependent protective effect on photoreceptor cells against damage mediated by blue light LED exposure.Jul 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mar Drugs. 2020 Jul 25 ;18(8). Epub 2020 Jul 25. PMID: 32722441

Article Published Date : Jul 24, 2020

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Blue Light Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Bilberry and lingonberry containing anthocyanidins, procyanidin, and resveratrol exert protective effects against blue LED light-induced retinal photoreceptor cell damage.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2014 ;14:120. Epub 2014 Apr 2. PMID: 24690313

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Bilberry, Lingonberry, Polyphenols, Proanthocyanidins, Resveratrol

Diseases : Retinal Degeneration: Light-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor

Additional Keywords : Light-Emitting Diodes (LEDs), Phytotherapy, Plant Extracts

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue LED light increased reactive oxygen species production.Jun 08, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2014 Jun 9 ;4:5223. Epub 2014 Jun 9. PMID: 24909301

Article Published Date : Jun 08, 2014

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage, Photooxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light action on mitochondria leads to cell death by necroptosis.Aug 31, 2016

Click here to read the entire abstract

Pubmed Data : Neurochem Res. 2016 Sep ;41(9):2324-35. Epub 2016 May 23. PMID: 27216620

Article Published Date : Aug 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Oxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm)

Adverse Pharmacological Actions : Apoptotic

[+]

Blue light effect on retinal pigment epithelial cells by display devices.Jan 21, 2017

Click here to read the entire abstract

Pubmed Data : Integr Biol (Camb). 2017 05 22 ;9(5):436-443. PMID: 28386617

Article Published Date : Jan 21, 2017

Study Type : In Vitro Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

Adverse Pharmacological Actions : Apoptotic

[+]

Blue light exposure can induce damages to human retinal pigment epithelium cells in vitroNov 30, 2006

Click here to read the entire abstract

Pubmed Data : Zhonghua Yan Ke Za Zhi. 2006 Dec ;42(12):1095-102. PMID: 17415967

Article Published Date : Nov 30, 2006

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

Adverse Pharmacological Actions : Apoptotic

[+]

Blue light exposure in vitro causes toxicity to trigeminal neurons and glia.Jan 31, 2019

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2019 Feb 1 ;131:27-39. Epub 2018 Nov 27. PMID: 30496813

Article Published Date : Jan 31, 2019

Study Type : In Vitro Study

Additional Links

Diseases : Blue Light Toxicity, Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light exposure over threshold can induce damage to human retinal pigment epithelium cells.Dec 31, 2004

Click here to read the entire abstract

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jan ;36(1):57-9, 96. PMID: 15702781

Article Published Date : Dec 31, 2004

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light induces mitochondrial DNA damage and free radical production in epithelial cells.Jun 02, 2005

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biol Chem. 2005 Jun 3 ;280(22):21061-6. Epub 2005 Mar 29. PMID: 15797866

Article Published Date : Jun 02, 2005

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light irradiation inhibits the production of hepatocyte growth factor by human retinal pigment epithelium cells.Aug 31, 2006

Click here to read the entire abstract

Pubmed Data : Photochem Photobiol. 2006 Sep-Oct;82(5):1247-50. PMID: 16740060

Article Published Date : Aug 31, 2006

Study Type : In Vitro Study

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light negatively affects the survival of ARPE19 cells through an action on their mitochondria and blunted by red light.Sep 08, 2018

Click here to read the entire abstract

Pubmed Data : Acta Ophthalmol. 2018 Sep 9. Epub 2018 Sep 9. PMID: 30198155

Article Published Date : Sep 08, 2018

Study Type : In Vitro Study

Additional Links

Therapeutic Actions : Light Therapy: Red Colored

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions.Jul 20, 2018

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2018 Jul 21 ;126:27-40. Epub 2018 Jul 21. PMID: 30040995

Article Published Date : Jul 20, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Dry Eye Syndromes, Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light-absorbing intraocular lenses further reduced damage compared to the conventional intraocular lenses.Jan 31, 2010

Click here to read the entire abstract

Pubmed Data : Ophthalmologe. 2010 Feb ;107(2):150-7. PMID: 19499230

Article Published Date : Jan 31, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Macular Degeneration

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Blue light-induced gene expression alterations in cultured neurons are the result of phototoxic interactions with neuronal culture media.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : eNeuro. 2020 Jan/Feb;7(1). Epub 2020 Jan 6. PMID: 31879366

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Diseases : Blue Light Toxicity

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Gene Expression Regulation

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Carbonylated proteins exposed to UVA and to blue light generate reactive oxygen species through a type I photosensitizing reaction.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : J Dermatol Sci. 2016 Dec ;84(3):314-321. Epub 2016 Sep 28. PMID: 27743910

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

Additional Links

Therapeutic Actions : Sunlight exposure

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Deep yellow lenses may protect retinal photoreceptor cells from blue LED light.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : J Biomed Opt. 2016 Mar ;21(3):35004. PMID: 27008925

Article Published Date : Feb 29, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Retinal Degeneration: Light-Induced

Therapeutic Actions : Amber Lenses, Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Effects of blue light on the circadian system and eye physiology.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Vis. 2016 ;22:61-72. Epub 2016 Jan 24. PMID: 26900325

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Establishment of a blue light damage model of human retinal pigment epithelial cells in vitro.Jun 23, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Genet Mol Res. 2016 Jun 24 ;15(2). Epub 2016 Jun 24. PMID: 27420965

Article Published Date : Jun 23, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Evidence for the role of blue light in the development of uveal melanoma.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ophthalmol. 2015 ;2015:386986. Epub 2015 May 17. PMID: 26075084

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Melanoma: Uveal

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Hydroxytyrosol might be proposed as an encouraging candidate for the prevention of blue light-induced premature photoaging.May 31, 2019

Click here to read the entire abstract

Pubmed Data : J Cell Physiol. 2019 Jun ;234(6):9065-9076. Epub 2018 Oct 26. PMID: 30367495

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Blue Light Toxicity

Pharmacological Actions : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Impairment of extramitochondrial oxidative phosphorylation in mouse rod outer segments by blue light irradiation.May 31, 2016

Click here to read the entire abstract

Pubmed Data : Biochimie. 2016 Jun ;125:171-8. Epub 2016 Apr 6. PMID: 27059514

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Oxidative Stress, Retinal Degeneration: Light-Induced

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

In vitro nonlethal blue light exposure led to cellular damage of staurosporine-differentiated RGC-5 cells. May 31, 2015

Click here to read the entire abstract

Pubmed Data : Photochem Photobiol Sci. 2015 Jun ;14(6):1093-9. PMID: 25877548

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Increased usage of smartphones during COVID-19: Is that blue light causing skin damage?Sep 30, 2020

Click here to read the entire abstract

Pubmed Data : J Cosmet Dermatol. 2020 Oct ;19(10):2466-2467. Epub 2020 Aug 26. PMID: 33460228

Article Published Date : Sep 30, 2020

Study Type : Review

Additional Links

Diseases : Blue Light Toxicity, Skin Diseases: Photo-Aging

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

L-type calcium channel α1D subunit may be involved in blue light induced damage on human retinal pigment epithelial cells.Oct 31, 2014

Click here to read the entire abstract

Pubmed Data : Zhonghua Yan Ke Za Zhi. 2014 Nov ;50(11):814-9. PMID: 25582206

Article Published Date : Oct 31, 2014

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Low-energy and low exposure times to high-energy blue light can help prevent skin diseases.Feb 28, 2021

Click here to read the entire abstract

Pubmed Data : J Cosmet Dermatol. 2021 Mar ;20(3):714-717. Epub 2020 Nov 28. PMID: 33247615

Article Published Date : Feb 28, 2021

Study Type : Review

Additional Links

Diseases : Blue Light Toxicity, DNA damage, Skin Diseases

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes.Sep 14, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Free Radic Biol Med. 2012 Sep 15 ;53(6):1298-307. Epub 2012 Jun 23. PMID: 22732187

Article Published Date : Sep 14, 2012

Study Type : In Vitro Study

Additional Links

Substances : Lutein, Zeaxanthin

Diseases : Macular Degeneration, Photooxidative Stress

Pharmacological Actions : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Maqui berry may be a useful protective agent for photoreceptors against the oxidative damage induced by exposure to blue light.Jan 01, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Med Ther. 2024 Jan 2 ;24(1):3. Epub 2024 Jan 2. PMID: 38167061

Article Published Date : Jan 01, 2024

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Maqui

Diseases : Blue Light Toxicity

Pharmacological Actions : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Mesenchymal stem cells-derived exosomes ameliorate blue light stimulation in retinal pigment epithelium cells and retinal laser injury.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Ophthalmol. 2018 ;11(4):559-566. Epub 2018 Apr 18. PMID: 29675371

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage

Additional Keywords : Exosomes, Mesenchymal Stem Cells

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Eye Res. 2017 01 ;154:151-158. Epub 2016 Dec 5. PMID: 27923559

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Macular Degeneration, Photooxidative Stress

Pharmacological Actions : Nrf2 activation

Additional Keywords : Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Oxidative stress is an early step leading to cellular damage by blue LED exposure.Sep 30, 2013

Click here to read the entire abstract

Pubmed Data : Free Radic Res. 2013 Oct ;47(10):774-80. Epub 2013 Aug 22. PMID: 23898883

Article Published Date : Sep 30, 2013

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage, Lipid Peroxidation, Photooxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2017 05 1 ;157(1):196-210. PMID: 28184904

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage

Pharmacological Actions : Apoptotic

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols.Nov 30, 2014

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2014 Dec ;74:216-24. PMID: 25447759

Article Published Date : Nov 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Grapefruit peel extract, Polyphenols

Diseases : Eye Damage, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic

Additional Keywords : Plant Extracts

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Preventive effect of Vaccinium uliginosum L. extract and its fractions on age-related macular degeneration and its action mechanisms.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2016 Jan ;39(1):21-32. Epub 2015 Nov 20. PMID: 26589689

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Macular Degeneration

Pharmacological Actions : Anti-Apoptotic

Additional Keywords : Plant Extracts

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Recent studies provide an updated clinical perspective on blue light-filtering intraocular lenses.Jun 30, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2011 Jul ;249(7):957-68. Epub 2011 May 17. PMID: 21584764

Article Published Date : Jun 30, 2011

Study Type : Review

Additional Links

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Restoring the anti-oxidative capabilities of the retina by increasing intake of lutein and zeaxanthin reduces the likelihood of AMD and cataract.Apr 30, 2011

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2011 May ;76(5):741-4. Epub 2011 Feb 26. PMID: 21354712

Article Published Date : Apr 30, 2011

Study Type : Review

Additional Links

Substances : Lutein, Zeaxanthin

Diseases : Cataract, Macular Degeneration, Photooxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Retinal protective effect of curcumin metabolite hexahydrocurcumin against blue light-induced RPE damage.Jan 31, 2023

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2023 Feb ;110:154606. Epub 2022 Dec 15. PMID: 36584606

Article Published Date : Jan 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Blue Light Toxicity, Macular Degeneration, Oxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Silibinin declines blue light-induced apoptosis and inflammation.Nov 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):4059-4065. PMID: 31631701

Article Published Date : Nov 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Blue Light Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

The dangers of blue light: True story!Apr 30, 2016

Click here to read the entire abstract

Pubmed Data : J Fr Ophtalmol. 2016 May ;39(5):483-8. Epub 2016 Mar 31. PMID: 27039979

Article Published Date : Apr 30, 2016

Study Type : Review

Additional Links

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

The effect of visual blue light on mitochondrial function associated with retinal ganglions cells.Oct 31, 2014

Click here to read the entire abstract

Pubmed Data : Exp Eye Res. 2014 Nov ;128:8-14. Epub 2014 Sep 2. PMID: 25193034

Article Published Date : Oct 31, 2014

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage, Glaucoma, Mitochondrial Diseases

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

The Nrf2 pathway plays an important role in protecting retinal pigment epithelium cells against blue light-induced oxidative stress.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:8694641. Epub 2016 Sep 27. PMID: 27774118

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Eye Damage, Oxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

These results suggest that blue light contributes to skin aging similar to UVA.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2017 07 ;108:300-310. Epub 2017 Mar 15. PMID: 28315451

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Aging Skin, Oxidative Stress

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Tinted glasses may provide significant protection against potential blue-light-induced photo-oxidative damage in retinal pigment epithelial cells.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Ophthalmic Res. 2017 ;57(2):118-124. Epub 2016 Nov 24. PMID: 27880954

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Macular Degeneration

Therapeutic Actions : Blue Light Blocking

Pharmacological Actions : Anti-Apoptotic

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells.Feb 17, 2019

Click here to read the entire abstract

Pubmed Data : Arch Toxicol. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30778631

Article Published Date : Feb 17, 2019

Study Type : In Vitro Study

Additional Links

Diseases : Blue Light Toxicity, Macular Degeneration

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Yellow-tinted intraocular lenses absorb more circadian rhythm-associated light than clear intraocular lenses.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Adv Exp Med Biol. 2018 ;1074:53-60. PMID: 29721927

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Therapeutic Actions : Amber Lenses, Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

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View the Evidence: 103 Abstracts with Blue Light (400−495 nm) Research

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Acute exposure to evening blue‐enriched light impacts on human sleep.Sep 30, 2013

Amber lenses could be used to block blue light and improve sleep.Nov 30, 2009

Amber lenses represent a safe, affordable, and easily implemented therapeutic intervention for insomnia symptoms.Dec 31, 2017

Blocking short-wavelength light in the evening hours may be beneficial for patients suffering from insomnia.Dec 31, 2019

Blue blocking glasses are effective and feasible as add‐on treatment for bipolar mania.Dec 31, 2015

Blue light-filtering toric intraocular lenses produced a significantly greater reduction in glare disability than the UV-only filtered lenses. Apr 30, 2012

Blue-blocking glasses may be useful as an adjunctive treatment for circadian rhythm issues in patients with bipolar disorder.Apr 09, 2020

Blue-light filtering spectacle lenses can partially filter high-energy short-wavelength light without substantially degrading visual performance.Dec 31, 2016

Blue-violet light irradiation dose dependently decreases carotenoids in human skin.Dec 31, 2014

Circadian phase, dynamics of subjective sleepiness and sensitivity to blue light in young adults complaining of a delayed sleep schedule.May 31, 2017

Effect of blue light-reducing eye glasses on critical flicker frequency.Feb 28, 2015

Exposure to blue light during lunch break: effects on autonomic arousal and behavioral alertness.Jul 10, 2017

Exposure to blue wavelength light modulates anterior cingulate cortex activation in response to 'uncertain' versus 'certain' anticipation of positive stimuli.Mar 10, 2016

High-energy blue light from visual display terminals can be a risk factor in the ocular surface damage.Jun 10, 2018

L. paracasei KW3110 suppressed blue light-induced retinal pigment epithelial cell death.Aug 08, 2018

Morning and evening blue-enriched light exposure alters metabolic function in normal weight adults.Dec 31, 2015

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

Pigmentation effects of blue light irradiation on skin and how to protect against them.Jul 31, 2020

Pupillary responses to high-irradiance blue light correlate with glaucoma severity.Aug 31, 2015

Sleep quality decreases with smartphone usage among people who do not usually use their smartphones before going to sleep and do not have any sleep problems.Mar 31, 2022

Suppression of vagal cardiac modulation by blue light in healthy subjects.Oct 04, 2016

The use of blue light smartphones was associated with significantly decreased sleepiness and confusion-bewilderment.Dec 31, 2016

These results further emphasize the interaction of light exposure with depression.Feb 28, 2018

This brings important concerns with regard to blue-enriched light therapy lamps used to treat SAD symptoms and other disorders.Jan 14, 2011

Use of modified spectacles and light bulbs to block blue light at night may prevent postpartum depression.Jul 31, 2009

Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder.Dec 31, 2015

Filtering blue light reduces light-induced oxidative stress, senescence and accumulation of extracellular matrix proteins in retinal cells.Dec 31, 2011

A case report of damage to the macula associated with LED-derived blue laser exposure.Apr 23, 2017

Protective effect of Ribes nigrum extract against blue light-induced retinal degeneration.Apr 24, 2022

Wolfberry water extract attenuates blue light-emitting diode damage to ARPE-19 cells and mouse retina.Apr 30, 2023

Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen.Oct 27, 2023

Blue light exposure led to a statistically significant increase in proliferation for cell lines derived from intraocular tumors.Apr 06, 2009

Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats.Apr 17, 2018

Blue light induced A2E oxidation in rat eyes.Oct 31, 2010

Blue light reduces melanopsin expression in intrinsically photoreceptive retinal ganglion cells and damages the inner retina.Jan 02, 2022

Blue-light filtering alters angiogenic signaling in human retinal pigmented epithelial cells culture modelNov 01, 2017

Cynaroside protects the blue light-induced retinal degeneration through alleviating apoptosis and inducing autophagy in vitro and in vivo.Jul 14, 2021

Daytime exposure to blue light alters cardiovascular circadian rhythms, electrolyte excretion and melatonin production.Mar 13, 2022

Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice.Jul 20, 2018

Light colour and intensity alters reproductive/seasonal responses in Japanese quail.Jul 31, 2015

Light regulates the expression of the BDNF/TrkB system in the adult zebrafish retina.Dec 31, 2012

Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors.Mar 05, 2023

Low-luminance blue light-enhanced phototoxicity in A2E-laden RPE cell cultures.Apr 10, 2019

Molecular mechanism of the protective effect of lutein against retinal damage induced by blue-light in rats.Oct 31, 2010

N-acetylcysteine protected against blue LED light-induced retinal damage in a dose-dependent manner.Dec 31, 2016

Neuroglobin is a potential biological marker of retinal damage induced by LED light.Jun 12, 2014

Overexposure to blue light with short wavelengths can induce oxidative damage and apoptosis to the cornea.Dec 31, 2015

Photo-oxidative blue-light stimulation in retinal pigment epithelium cells promotes exosome secretion and increases the activity of the NLRP3 inflammasome.Sep 09, 2018

Phototoxicity of LEDs on the retina is characterized by a strong damage of photoreceptors and by the induction of necrosis.Jun 30, 2015

Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light.Nov 30, 2016

Protective effect of Prunella vulgaris var. L extract against blue light induced damages in ARPE-19 cells and mouse retina.Dec 04, 2019

Rutin intake mitigates the injury of blue light irradiation by altering aging rates of mortality in Drosophila model.Sep 03, 2023

The blockade of blue plus additional visible wavelengths of light was most effective in protecting the retina from light-induced damage. Jul 31, 2014

The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance.Dec 16, 2016

The potential damage caused by blue light can be palliated.Dec 31, 2017

These results raise questions about adverse effects on the retina from chronic exposure to LED light compared with other light sources that have less blue light.Feb 28, 2014

These results suggest that L. paracasei KW3110 may have a preventive effect against degrative retinal diseases.Dec 14, 2018

Visual functional effects of constant blue light in a retinal degenerate rat model.Apr 30, 2007

A review of the effects and safety of the blue light on retinal cells.Dec 31, 2014

Astaxanthin exerted a dose-dependent protective effect on photoreceptor cells against damage mediated by blue light LED exposure.Jul 24, 2020

Bilberry and lingonberry containing anthocyanidins, procyanidin, and resveratrol exert protective effects against blue LED light-induced retinal photoreceptor cell damage.Dec 31, 2013

Blue LED light increased reactive oxygen species production.Jun 08, 2014

Blue light action on mitochondria leads to cell death by necroptosis.Aug 31, 2016

Blue light effect on retinal pigment epithelial cells by display devices.Jan 21, 2017

Blue light exposure can induce damages to human retinal pigment epithelium cells in vitroNov 30, 2006

Blue light exposure in vitro causes toxicity to trigeminal neurons and glia.Jan 31, 2019

Blue light exposure over threshold can induce damage to human retinal pigment epithelium cells.Dec 31, 2004

Blue light induces mitochondrial DNA damage and free radical production in epithelial cells.Jun 02, 2005

Blue light irradiation inhibits the production of hepatocyte growth factor by human retinal pigment epithelium cells.Aug 31, 2006

Blue light negatively affects the survival of ARPE19 cells through an action on their mitochondria and blunted by red light.Sep 08, 2018

Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions.Jul 20, 2018

Blue light-absorbing intraocular lenses further reduced damage compared to the conventional intraocular lenses.Jan 31, 2010

Blue Light (400−495 nm)

View the Evidence:
103 Abstracts with Blue Light (400−495 nm) Research