Article Publish Status: FREE
Abstract Title:

Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel.

Abstract Source:

Acta Cir Bras. 2015 Sep ;30(9):586-92. PMID: 26465101

Abstract Author(s):

Dênia Amélia Novato Castelli Von Atzingen, Adriana Rodrigues dos Anjos Mendonça, Marcos Mesquita Filho, Vinícius Alves Alvarenga, Vinícius Almeida Assis, Afonso Esteves Penazzo, Julio Henrique Muzetti, Thaisa Sousa Rezende

Article Affiliation:

Dênia Amélia Novato Castelli Von Atzingen


PURPOSE: To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats.

METHODS: A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28.

RESULTS: On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28.

CONCLUSION: The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.

Study Type : Animal Study

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