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Article Publish Status: FREE
Abstract Title:

1,25-Dihydroxyvitamin DProvides Benefits in Vitiligo Based on Modulation of CD8+ T Cell Glycolysis and Function.

Abstract Source:

Nutrients. 2023 Nov 6 ;15(21). Epub 2023 Nov 6. PMID: 37960350

Abstract Author(s):

Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Zhong Liu, Ying Zeng, Ronghua Pan, Ri Zhang, Yunhua Deng, Dong Li

Article Affiliation:

Yujia Wei

Abstract:

Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃[1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic option in various autoimmune diseases. This study aimed to elucidate the immunomodulatory effects of 1,25(OH)₂D₃in vitiligo. Cross-sectional relationships between serum 1,25(OH)₂D₃levels and disease characteristics were investigated in 327 patients with vitiligo. The immunomodulatory and therapeutic effects of 1,25(OH)₂D₃were then investigated in vivo and in vitro, respectively. We found that 1,25(OH)₂D₃deficiency was associated with hyperactivity of CD8+ T cells in the vitiligo cohort. In addition, 1,25(OH)₂D₃suppressed glycolysis by activating the AMP-activated protein kinase (AMPK) signaling pathway, thereby inhibiting the proliferation, cytotoxicity and aberrant activation of CD8+ T cells. Finally, the in vivo administration of 1,25(OH)₂D₃to melanocyte-associated vitiligo (MAV) mice reduced the infiltration and function of CD8+ T cells and promoted repigmentation. In conclusion, 1,25(OH)₂D₃may serve as an essential biomarker of the progression and severity of vitiligo. The modulation of autoreactive CD8+ T cell function and glycolysis by 1,25(OH)₂D₃may be a novel approach for treating vitiligo.

Study Type : Human Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(5935) : AC(2217)

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