Article Publish Status: FREE
Abstract Title:

Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats.

Abstract Source:

J Dent Sci. 2018 Dec ;13(4):334-341. Epub 2018 Jul 20. PMID: 30895142

Abstract Author(s):

Dyna Jeanne D Godoy, Jaroenporn Chokboribal, Ruben Pauwels, Wijit Banlunara, Polkit Sangvanich, Sukanya Jaroenporn, Pasutha Thunyakitpisal

Article Affiliation:

Dyna Jeanne D Godoy


Background/purpose: Acemannan, aβ-(1-4)-acetylated polymannose extracted fromgel, has been proposed as biomaterial for bone regeneration. The aim of this study was to investigate the effect of acemannan in calvarial defect healing.

Materials and methods: Acemannan was processed to freeze-dried sponge form and disinfected by UV irradiation. Thirty-five female Sprague-Dawley rats were used in thestudy. Seven-mm diameter mid-calvarial defects were created and randomly allocated into blood clot control (C), acemannan 1 mg (A1), 2 mg (A2), 4 mg (A4), and 8 mg (A8) groups (n = 7). After four weeks, the calvarial specimens were subjected to microcomputed tomography (microCT) and histopathological analysis.

Results: MicroCT revealed a significant increase in bone surface and bone volume in the A1 and A2 groups, and tissue mineral density in the A4 and A8 groups compared with the control group ( < 0.05). Histologically, the acemannan-treated groups had denser bone matrix compared with the control group.

Conclusion: Acemannan is an effective bioactive agent for bone regeneration, enhancing bone growth as assayed in two- and three-dimensions.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Osteoprotective : CK(971) : AC(351)

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