Abstract Title:

Evaluation of glycemic and lipid profile of offspring of diabetic Wistar rats treated with Malpighia emarginata juice.

Abstract Source:

Exp Diabetes Res. 2011;2011:173647. Epub 2011 Jan 23. PMID: 21318139

Abstract Author(s):

Sandra M Barbalho, Débora C Damasceno, Ana Paula Machado Spada, Miréia Palhares, Karla Aparecida Martuchi, Marie Oshiiwa, Viviane Sazaki, Vanessa Sellis da Silva

Article Affiliation:

Medical School of Medicine of Marília, Faculty of Technology and Foods of Marília, Avenida Higino Muzzi Filho 1001, Marília, SP, Brazil. [email protected]


Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.

Study Type : Animal Study

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