Acetyl ethyl tetramethyl tetralin (AETT), a component fragrance of soaps, deodorants, and cosmetics, produces ceroid and myelin disease in an animal model. - GreenMedInfo Summary
Abstract Title:
Neurotoxic fragrance produces ceroid and myelin disease.
Abstract Source:
Science. 1979 May 11;204(4393):633-5. PMID: 432669
Abstract:
Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.
Article Published Date : May 11, 1979
Study Type : Animal Study
Additional Links
Diseases : Ceroid-Lipofuscinosis: Neuronal : CK(2) : AC(1), Demyelinating Diseases : CK(2740) : AC(589)
Problem Substances : Acetyl ethyl tetramethyl tetralin (AETT) : CK(2) : AC(1), Perfume: Synthetic : CK(2) : AC(1)
