Abstract Title:

Mutagenicity of acrylamide and its analogues in Salmonella typhimurium.

Abstract Source:

Mutat Res. 1985 Dec;158(3):129-33. PMID: 3908926

Abstract Author(s):

K Hashimoto, H Tanii


Acrylamide and its 15 analogues have been tested for mutagenicity in 5 TA strains of Salmonella typhimurium. Acrylamide, N-tert-butylacrylamide, crotonamide, diacetone acrylamide, N,N-diethylacrylamide, N,N-dimethylacrylamide, N-hydroxymethylacrylamide, N-methylacrylamide, N-isobutoxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N,N'-methylene-bis-acrylamide and N-tert-octylacrylamide appeared not to be mutagenic in the standard Ames assay both with and without Aroclor 1254-induced S9, and in both the plate incubation and liquid preincubation procedures. Three epoxide analogues, i.e., glycidamide, N,N-diglycidyl acrylamide and glycidyl methacrylamide showed mutagenicity in one or two strains both with and without the S9.

Study Type : In Vitro Study
Additional Links
Problem Substances : Acrylamide : CK(97) : AC(40)
Adverse Pharmacological Actions : Mutagenic : CK(29) : AC(17)

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