Abstract Title:

[Effect of scalp-acupuncture on energy metabolism of brain tissue in intracerebral hemorrhage rats].

Abstract Source:

Zhen Ci Yan Jiu. 2008 Apr;33(2):93-7. PMID: 18630583

Abstract Author(s):

Chun-Ling Bao, Hong-Sheng Dong

Article Affiliation:

Yueyang Hospital of Shanghai University of Chinese Medicine, Shanghai 200437, China. [email protected]


OBJECTIVE: To observe the effect of electroacupuncture (EA) on mitochondrial SDH and Na+ -K+ -ATPase activity, and lactate acid (LA) content in the peri-hemotoma tissue in rats with intracerebral hemorrhage (ICH) so as to explore its mechanisms in resisting cerebral ischemia. METHODS: A total of 80 Wistar rats were randomized into normal group, sham group, model group, EA group. The last three groups were further divided into 24 h, 72 h and 168 h subgroups respectively, with 8 cases in each group/subgroups. ICH model was established by caudatum-injection (right) of Collagense VII/heparini solution (2 microl). EA (2 Hz, 1 mA) was applied to "Baihui" (GV 20)-"Taiyang" (EX-HN 5) for 30 min. Chondriosome suspension of the cerebral perihemotoma tissue was got by gradient centrifugation for detecting SDH and Na+ -K+ -ATPase activity, and LA content with chromometry. RESULTS: In comparison with sham-operation group and control group, SDH and mitochondrial Na+ -K+ -ATPase activity in cerebral peri-hemotoma tissue declined significantly from 72 h and 24 h on respectively (P<0.05), while LA level increased markedly from 24 h on (P<0.05) in model group. Compared with sham-operation group, SDH activity (168 h) and Na+ -K+ -ATPase activity (24 h, 72 h and 168 h) in EA group also decreased significantly (P<0.05); LA level (24 h, 72 h) in EA group increased considerably (P<0.05). Whereas compared with model group, SDH and Na+ -K+ -ATPase activity increased significantly at most time courses (P<0.05), and LA level decreased remarkably (P<0.05) in EA group. CONCLUSION: EA can improve the energy metabolism, upregulate the activity of chondriosome,and reduce the accumulation of LA in the cerebral perihemotoma tissue of ICH rats.

Study Type : Animal Study
Additional Links
Therapeutic Actions : Acupuncture : CK(3141) : AC(370)

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