Article Publish Status: FREE
Abstract Title:

Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis.

Abstract Source:

Breast Cancer Res Treat. 2013 Jun ;139(2):391-401. Epub 2013 May 29. PMID: 23715631

Abstract Author(s):

Julia Hobson, Phani Gummadidala, Brian Silverstrim, Dore Grier, Janice Bunn, Ted James, Mercedes Rincon

Article Affiliation:

Julia Hobson


Development of metastasis in peripheral tissues is a major problem in the fight to cure breast cancer. Although it is becoming evident that chronic inflammation can contribute to tumor progression and metastasis, the effect of acute inflammation in primary tumor is less known. Using mouse models for breast cancer here we show that biopsy of mammary tumors increases the frequency of lung metastases. This effect is associated with the recruitment of inflammatory cells to the lung and elevated levels of certain cytokines such as IL-6 in the lung airways. Antiinflammatory treatment prior to and after the biopsy reduces the development of metastases triggered by the biopsy. In addition, while lack of IL-6 does not affect primary tumor development, it protects from increasing number of metastases upon biopsy. Thus, our studies show that in addition to chronic inflammation, acute immune response caused by invasive procedures in the primary tumor may cause an increased risk on peripheral metastases, but the risk could be decreased by anti-inflammatory treatments.

Study Type : Animal Study

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Sayer Ji
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