Abstract Title:

Acute interstitial nephritis due to mesalazine.

Abstract Source:

Nephrology (Carlton). 2005 Apr;10(2):103-5. PMID: 15877665

Abstract Author(s):

Mario Tadic, Ivica Grgurevic, Mira Scukanec-Spoljar, Borka Bozic, Srecko Marusic, Ivica Horvatic, Kresimir Galesic

Article Affiliation:

Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia. [email protected]


A case of mesalazine-induced acute interstitial nephritis (AIN) in a 41-year-old patient with ulcerative colitis (UC) is reported here. Clinical symptoms such as fever and arthralgia, and laboratory findings such as eosinophilia and renal failure suggested AIN, which was confirmed by biopsy. With withdrawal of mesalazine and intravenous methylprednisolone the patient's renal function was recovered. It is observed that early discontinuation of mesalazine is associated with amelioration of interstitial nephritis in most patients, so the recommendation is that patients receiving mesalazine should undergo routine monitoring of renal function. Delayed diagnosis may lead to permanent renal function impairment.

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