Abstract Title:

Acute supplementation with beetroot juice improves endothelial function in HIV-infected individuals.

Abstract Source:

Appl Physiol Nutr Metab. 2020 Aug 31. Epub 2020 Aug 31. PMID: 32866396

Abstract Author(s):

Rogerio Nogueira Soares, Ana Paula Machado-Santos, Elisa Barros-Santos, Gustavo Vieira Oliveira, Juan M Murias, Thiago Alvares

Article Affiliation:

Rogerio Nogueira Soares


Human immunodeficiency virus (HIV) is associated with lower nitric oxide (NO) bioavailability and vascular dysfunction. Nitrate-rich beetroot juice (BJ) has been shown to acutely increase NO availability and vascular function in healthy and individuals at high risk for CVD . Thus, we tested the effects of BJ ingestion on flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in healthy and HIV-infected patients. 13 HIV-infected (36±10 years old) and 18 healthy (27±8 years old) participated in the study. Individuals were submitted to vascular tests such as FMD and pulse PWV at pre (T0) and at 120 min (T120) after beetroot juice (BJ) and placebo (PLA) ingestion. The %FMD at T0 of the control group was significantly higher than the %FMD at T0 of the HIV individuals in both interventions. BJ improved the %FMD at T120 when compared to T0 in the HIV and control groups. There was no change in %FMD after PLA ingestion in the control and HIV groups. There were no differences between groups (control vs HIV), time points (T0 vsT120) and interventions (BJ vs PLA) for PWV. Our findings showed that nitrate-rich beetroot juice ingestion acutely improved vascular function in healthy and HIV-infected patients. Clinical Trials Registry number: NCT03485248. Novelty bullets: ●Human immunodeficiency virus (HIV) is associated withlower nitric oxide (NO) bioavailability and vascular dysfunction. ●Acute supplementation with nitrate-rich beetroot juice (BJ) has been shown to acutely increases NO bioavailability ●We showed for the first time that BJ acutely improve endothelial function in HIV-infected patients.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.