Abstract Title:

Acute renal failure with acyclovir treatment in a child with leukemia.

Abstract Source:

Drug Chem Toxicol. 2010 Apr;33(2):217-9. PMID: 20307148

Abstract Author(s):

Gürkan Genc, Ozan Ozkaya, Yonca Acikgöz, Oktay Yapici, Kenan Bek, Sema Gülnar Sensoy, Emel Ozyürek

Article Affiliation:

Department of Pediatric Nephrology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey. [email protected]


Acyclovir is an effective, frequently used antiviral agent. Adverse effects of this drug are well known and are especially seen with high doses and/or dehydration. In this article, we report a 6-year-old boy with leukemia with nonoliguric acute renal failure in normal hydration status after using acyclovir treatment. He had no preexisting renal impairment, and there were no additional symptoms. Dimercaptosuccinic acid radionucleid scyntigraphy and other laboratory findings revealed impairment of proximal tubule function, in addition to distal tubule. We emphasize that renal functions should be monitored carefully during treatment with acyclovir, and asymptomatic nephrotoxicity must be kept in mind.

Study Type : Human Study
Additional Links
Problem Substances : Acyclovir : CK(74) : AC(10)

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