Article Publish Status: FREE
Abstract Title:

Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress.

Abstract Source:

PLoS One. 2018 ;13(1):e0191889. Epub 2018 Jan 29. PMID: 29377921

Abstract Author(s):

Douglas Carvalho Caixeta, Renata Roland Teixeira, Leonardo Gomes Peixoto, Helen Lara Machado, Nathalia Belele Baptista, Adriele Vieira de Souza, Danielle Diniz Vilela, Celso Rodrigues Franci, Foued Salmen Espindola

Article Affiliation:

Douglas Carvalho Caixeta


Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ.

Study Type : Animal Study

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