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Article Publish Status: FREE
Abstract Title:

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

Abstract Source:

iScience. 2022 Nov 18 ;25(11):105214. Epub 2022 Sep 26. PMID: 36281450

Abstract Author(s):

He Li, Yawei Du, Hanrui Ji, Yanan Yang, Changchang Xu, Qiaodan Li, Longkai Ran, Chongming Wu, Qile Zhou, Shengxian Wu

Article Affiliation:

He Li

Abstract:

is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering and anti-atherosclerotic effects. However, its main active components and potential mechanisms still remain unclear. Here, we evaluated the anti-hyperlipidemic effect of the adenosine extract from(AEGL) in high-fat-diet (HFD)-induced hyperlipidemic ApoEmice and explored the underlying biological mechanism by multi-omics analysis. Treatment with AEGL for 8 weeks significantly decreased the serum levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) by 45.59%, 41.22%, and 39.02%, respectively, as well as reduced liver TC and TG by 44.15% and 76.23%, compared with the HFD-only group. We also observed significant amelioration of hepatic steatosis without liver and kidney damage after AEGL treatment. Regulating the expression and acetylation/crotonylation of proteins involved in the PPAR signaling pathway may be one of the potential mechanisms involved in the observed lipid-lowering effects of AEGL.

Study Type : Animal Study

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