Abstract Title:

Medications do not necessarily normalize cognition in ADHD patients.

Abstract Source:

J Atten Disord. 2008 Jan;11(4):459-69. Epub 2007 Oct 12. PMID: 17934180

Abstract Author(s):

C Thomas Gualtieri, Lynda G Johnson

Article Affiliation:

North Carolina Neuropsychiatry Clinics, Chapel Hill, NC 27514, USA. [email protected]


OBJECTIVE: Although ADHD medications are effective for the behavioral components of the disorder, little information exists concerning their effects on cognition, especially in community samples. METHOD: A cross-sectional study of ADHD patients treated with three different ADHD drugs was conducted. Patients' performance on a computerized neurocognitive screening battery was compared to untreated ADHD patients and normal controls (NML). A total of 177 ADHD patients aged 10 to 18, achieved a favorable response to one of the following medications: Adderall XR (AMP), atomoxetine (ATMX), and Concerta (MPH-OROS) compared to 95 untreated ADHD patients and 101 NML. RESULTS: Significant differences were detected between normals and untreated ADHD patients. Treated patients performed better than untreated patients but remained significantly impaired compared to normal subjects. CONCLUSION: Even with optimal treatment, based on parents' and teachers' opinions, subtle and not-so-subtle neurocognitive impairments persisted in the ADHD patients. Some ADHD patients may require additional educational assistance, even in the face of successful medication treatment.

Study Type : Human Study

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