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Article Publish Status: FREE
Abstract Title:

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile.

Abstract Source:

Nat Prod Bioprospect. 2020 Jun ;10(3):163-170. Epub 2020 May 23. PMID: 32447748

Abstract Author(s):

Hui-Min Zhou, Yan-Song Ye, Na-Na Jiang, Rong-Fang Mu, Qian Wang, Jing Hu, Xia Liu, Wan-Ying Qin, Gang Xu, Wen-Yong Xiong

Article Affiliation:

Hui-Min Zhou

Abstract:

Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

Study Type : In Vitro Study

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