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Abstract Title:

Adlay seed extract (Coix lachryma-jobi L.) decreased adipocyte differentiation and increased glucose uptake in 3T3-L1 cells.

Abstract Source:

J Med Food. 2010 Dec ;13(6):1331-9. PMID: 21091246

Abstract Author(s):

Do Thi Ha, Trinh Nam Trung, Nguyen Bich Thu, Tran Van On, Nguyen Hai Nam, Chu Van Men, Tran Thi Phuong, KiHwan Bae

Article Affiliation:

Do Thi Ha

Abstract:

The aim of the present study was to investigate effects of the ethyl acetate fraction of an ethanol extract of Coix lachryma-jobi (ECLJ) on glucose uptake and adipocyte differentiation in 3T3-L1 cells. ECLJ phosphorylated AMP-activated protein kinase (AMPK) and its downstream substrate acetyl-coenzymeA carboxylase in 3T3-L1 cells in a time- and dose-dependent manner. Moreover, we discovered that compound C inhibits ECLJ-stimulated ACC phosphorylation. In addition, ECLJ exhibited a dose-dependent stimulation of glucose uptake in 3T3-L1 cells, and this increase was obviously attenuated by compound C. ECLJ also caused a decrease in the expression levels of adipogenesis factors such as fatty acid synthase, sterol-regulatory-element-binding protein-1c, peroxisome proliferator-activated receptorγ, and CAATT/enhancer binding protein α in a dose-dependent manner. Differentiation was examined by Oil red O staining activity after ECLJ treatment for 6 days. ECLJ decreased mean droplet size. These results suggest a possible role for AMPK in the process of adipose differentiation and that ECLJtargeted for adipocyte functions could be effective in improving the symptoms of metabolic syndrome.

Study Type : In Vitro Study

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