Administration of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI improves cognitive and memory function. - GreenMedInfo Summary
Administration ofBGN4 andBORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer's Disease.
Front Aging Neurosci. 2021 ;13:709091. Epub 2021 Aug 6. PMID: 34421576
Hongwon Kim
Recent evidence indicates that gut microbiota could interact with the central nervous system and affect brain function, including cognition and memory. In this study, we investigated whetherBGN4 (BGN4)BORI (BORI) alleviated the pathological features in a mouse model of Alzheimer's disease (AD). Administration ofBGN4 andBORI effectively suppressed amyloidosis and apoptotic processes and improved synaptic plasticity by ameliorating the neuroinflammatory response and BDNF expression. Moreover, behavioral tests indicated thatBGN4 andBORI attenuated the cognitive and memory disability of AD mice. Taken together, the present study highlights the therapeutic potential ofBGN4 andBORI for suppressing the pathological features of AD.