Article Publish Status: FREE
Abstract Title:

The oil of garlic, Allium sativum L. (Amaryllidaceae), as a potential protectant against Anisakis spp. Type II (L3) (Nematoda) infection in Wistar rats.

Abstract Source:

Rev Bras Parasitol Vet. 2021 ;30(1):e015920. Epub 2021 Feb 12. PMID: 33605386

Abstract Author(s):

Kareem Morsy, Ali Al Ghamdi, Saad Bin Dajem, Mashael Bin-Meferij, Ali Alshehri, Attalla El-Kott, Essam Ibrahim, Atef Ali, Hamida Hamdi, Amin Al-Doaiss, Sara Saber

Article Affiliation:

Kareem Morsy


The consumption of inadequately thermally treated fish is a public health risk due to the possible propagation of Anisakis larvae. The present study demonstrated the physiological and histopathological changes that accompanied an oral inoculation of crude extracts from fresh and thermally treated Anisakis Type II (L3) in rats. Worms were isolated from a marine fish and examined and identified using light and scanning electron microscopy. The study was performed in 6 rat groups: control (I), garlic oil (GO) inoculated (II), fresh L3 inoculated (III), thermally treated L3 inoculated (IV), fresh L3 + GO inoculated (V), and a thermally treated L3 + GO inoculated (VI) groups. Rats inoculated with fresh and thermally treated L3 showed abnormal liver and kidney functions associated with the destruction of normal architecture. GO produced a protective effect in rat groups inoculated with L3 extracts + GO via the amelioration of liver and kidney functions, which was confirmed by the marked normal structure on histology. Cooking of L3-infected fish induced severe alterations compared to uncooked fish. The administration of garlic before and after fish eating is recommended to avoid the dangerous effect of anisakids, even if they are cooked.

Study Type : Animal Study

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