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Article Publish Status: FREE
Abstract Title:

Advances in Anti-Cancer Activities of Flavonoids in: Perspectives on Mechanism.

Abstract Source:

Int J Mol Sci. 2022 Sep 20 ;23(19). Epub 2022 Sep 20. PMID: 36232344

Abstract Author(s):

Yiqing Gu, Qi Zheng, Guifang Fan, Runping Liu

Article Affiliation:

Yiqing Gu

Abstract:

Despite encouraging progresses in the development of novel therapies, cancer remains the dominant cause of disease-related mortality and has become a leading economic and healthcare burden worldwide.(SR,in Chinese) is a common herb used in traditional Chinese medicine, with a long history in treating a series of symptoms resulting from cancer, like dysregulated immune response and metabolic abnormalities. As major bioactive ingredients extracted from SR, flavonoids, including baicalein, wogonin, along with their glycosides (baicalin and wogonoside), represent promising pharmacological and anti-tumor activities and deserve extensive research attention. Emerging evidence has made great strides in elucidating the multi-targeting therapeutic mechanisms and key signaling pathways underlying the efficacious potential of flavonoids derived from SR in the field of cancer treatment. In this current review, we aim to summarize the pharmacological actions of flavonoids against various cancers in vivo and in vitro. Moreover, we also make a brief summarization of the endeavor in developing a drug delivery system or structural modification to enhance the bioavailability and biological activities of flavonoid monomers. Taken together, flavonoid components in SR have great potential to be developed as adjuvant or even primary therapies for the clinical management of cancers and have a promising prospect.

Study Type : Review

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