Abstract Title:

[Advances on anti-tumor mechanisms of zerumbone].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2020 Jun ;45(12):2817-2826. PMID: 32627455

Abstract Author(s):

Hong Yang, Rong-Mei Dou, Ting Yao, Dao-Peng Gui, Xue-Wen Jang, Jun-Jun Li, Fu-Xing Ge, Xiao-Li Gao, Xing-Yun Chai

Article Affiliation:

Hong Yang


Zerumbone(ZER), one of humulane-type sesquiterpenoids, showed its unique advantage against tumor activities. The main underlying mechanisms include inhibiting the growth and proliferation of cancer cells, inducing apoptosis of cancer cells and differentiation of cancer cells, regulating immune function, inhibiting invasion and metastasis of cancer cells, and reversing multidrug resistance of cancer cells. Studies on ZER focusing its cytotoxic or anti-tumor is one of hot topic. Currently, with the increasing studies on ZER, the clarified mechanisms are getting rich. The present paper describes a summary of its anti-tumor mechanism of action and helps to provide significant reference to more in-depth research.

Study Type : Review

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