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Article Publish Status: FREE
Abstract Title:

Leaf Extract Phytochemical Analysis, Cytotoxicity, In Vitro Antioxidant and Antidiabetic Activities.

Abstract Source:

Plants (Basel). 2021 Nov 25 ;10(12). Epub 2021 Nov 25. PMID: 34961044

Abstract Author(s):

Wasim Ahmad, Mohd Amir, Adil Ahmad, Abuzer Ali, Amena Ali, Shadma Wahab, Harshita Abul Barkat, Mohammad Azam Ansari, Mohammad Sarafroz, Ayaz Ahmad, Md Abul Barkat, Prawez Alam

Article Affiliation:

Wasim Ahmad

Abstract:

For many years,() has been used medicinally and as a dietary supplement. Despite this, there are minimal research data onphytochemical properties and pharmacological effects. This study aimed to explore the phytoconstituents, cytotoxicity, glucose uptake, and antioxidant and antidiabetic potential of an alcoholic extract ofleaf. The cytotoxicity ofin HepG2 cells was tested in vitro, and the results revealed that it has strong cytocompatibility and cytoprotective properties. The extract's antioxidant activities were investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods. Antioxidant potential was shown to be quite impressive. The enzymesα-amylase and α-glycosidase were found to be substantially inhibited by, with ICvalues of 46.21 and 42.07 mg/mL, respectively. In HepG2 cells,significantly reduced ROS levels that were elevated due to high glucose and enhanced glucose consumption (<0.05). These activities might be due to the enrichment of bioactive phytoconstituents analyzed chromatographically using GC/MS and HPLC. The findings of this study show thatcould be an effective restorative therapy for diabetes and related diseases.

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