Abstract Title:

Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages.

Abstract Source:

Mem Inst Oswaldo Cruz. 2008 May;103(3):244-50. Epub 2008 Apr 30. PMID: 18545860

Abstract Author(s):

Priscila Raquel Martins, Maria Carolina Gameiro, Lindsey Castoldi, Graziela Gorete Romagnoli, Fabiane Catanho Lopes, Andréa Vanessa Ferreira da Silva Pinto, Wagner Loyola, Ramon Kaneno


A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.

Study Type : Animal Study

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