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Article Publish Status: FREE
Abstract Title:

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway.

Abstract Source:

Mol Med Rep. 2020 02 ;21(2):675-684. Epub 2019 Dec 13. PMID: 31974628

Abstract Author(s):

Yong Zhang, Qiuyan Weng, Jinming Han, Jianming Chen

Article Affiliation:

Yong Zhang

Abstract:

Osteosarcoma is the most common type of malignant bone cancer and results in cancer‑related deaths among adolescents. Alantolactone (ALT) demonstrates antitumor properties in various diseases; however, its potential role in osteosarcoma is relatively unclear. The aim of the present study was to evaluate the effect of ALT on osteosarcoma. ALT significantly decreased the viabilityof U2OS and HOS osteosarcoma cell lines. Cells flow cytometry assay and Hoechst 33258 staining assay revealed that ALT significantly increased the proportion of apoptotic U2OS cells. In addition, wound healing and Transwell invasion assays demonstrated that the invasion and migration of osteosarcoma were markedly reduced upon ALT treatment. It was hypothesized that the antitumor functions of ALT are mediated through inhibition of the PI3K/AKT signaling pathway. In conclusion, the results of the present study confirmed the inhibition of ALT on osteosarcoma cells via downregulation of PI3K/AKTsignaling pathways, suggesting ALT as a potential therapeutic candidate for osteosarcoma.

Study Type : In Vitro Study

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Sayer Ji
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