n/a
Article Publish Status: FREE
Abstract Title:

Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressingandin mice.

Abstract Source:

Food Funct. 2021 Nov 1 ;12(21):10750-10763. Epub 2021 Nov 1. PMID: 34608923

Abstract Author(s):

Dong-Yun Lee, Yoon-Jung Shin, Jeon-Kyung Kim, Hyo-Min Jang, Min-Kyung Joo, Dong-Hyun Kim

Article Affiliation:

Dong-Yun Lee

Abstract:

Bacterial lipopolysaccharide (LPS) is a risk factor for the outbreak of Alzheimer's disease. Therefore, we isolatedNK151 andNK173 from a human fecal bacteria collection, which inhibitedLPS production, and examined their effects on theK1- or LPS-induced cognitive impairment in mice. Oral gavage of NK151, NK173, or their (4 : 1) mixture (NKm) significantly alleviatedK1-induced cognitive impairment-like behaviors in the Y-maze and novel object recognition tasks. Their treatments decreased IL-1β, IL-6, and TNF-α expression and NF-κB/Iba1and LPS/Iba1cell populations in the hippocampus, while the brain-derived neurotrophic factor (BDNF)/neuronal nuclei (NeuN)cell population and BDNF to proBNDF expression increased. They suppressed LPS-induced cognition impairment-like behaviors and neuroinflammation marker levels in the hippocampus. Treatment with them reducedK1- or LPS-induced LPS and apolipoprotein E levels in the blood and inflammatory marker levels in the colon. Furthermore, treatment with them modulated fecal Proteobacteria, Bacteroidetes, and Verrucomicrobia populations. Of these gut bacteria, Bacteroidaceae, Odoribacteraceae, Lactobacillaceae, Bifidobacteriaceae, Rikenellaceae, Helicobacteraceae, and Deferribacteraceae are correlated with cognitive function and blood and fecal LPS levels. These findings suggest that NK151 and NK173 may alleviate cognitive impairment with colitis by upregulating NF-κB-mediated BDNF expression through the suppression of fecal and blood bacterial LPS levels.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.