Article Publish Status: FREE
Abstract Title:

Alleviation Effects ofsubsp.XLTG11 on Dextran Sulfate Sodium-Induced Colitis in Mice.

Abstract Source:

Microorganisms. 2021 Oct 3 ;9(10). Epub 2021 Oct 3. PMID: 34683415

Abstract Author(s):

Nana Wang, Song Wang, Baofeng Xu, Fei Liu, Guicheng Huo, Bailiang Li

Article Affiliation:

Nana Wang


Inflammatory bowel disease (IBD) is a chronic immune-related disease, which can occur through the dysfunction of the immune system caused by the imbalance of gut microbiota. Previous studies have reported the beneficial effects ofon colitis, while the related mechanisms behind these effects have not been fully elucidated. The aim of our study is to investigate the alleviation effect ofsubsp.XLTG11) on dextran sulfate sodium (DSS)-induced colitis and its potential mechanism. The results showed thatXLTG11 significantly decreased weight loss, disease activity index score, colon shortening, myeloperoxide activity, spleen weight, and colon tissue damage. Additionally,XLTG11 significantly decreased the levels of pro-inflammatory cytokines and increased the level of anti-inflammatory cytokine. Meanwhile, high doses ofXLTG11 significantly up-regulated the expression of tight junction proteins and inhibited activation of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MYD88)/nuclear factor-κB (NF-κB) signaling pathway. Furthermore,XLTG11 increased the gut microbiota diversity and modulated gut microbiota composition caused by DSS. Moreover, Spearman's correlation analysis also found that several specific gut microbiota were significantly correlated with colitis-related indicators. These results demonstrated thatXLTG11 can alleviate DSS-induced colitis by inhibiting the activation of the TLR4/MYD88/NF-κB signaling pathway, regulating inflammatory cytokines, improving intestinal barrier function, and modulating the gut microbiota.

Study Type : Animal Study

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