n/a
Article Publish Status: FREE
Abstract Title:

Allicin alleviates lead-induced hematopoietic stem cell aging by upregulating PKM2.

Abstract Source:

Biosci Rep. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31213573

Abstract Author(s):

Shi-Zhong Cai, Li-Na Zhao, Jun Liu, Yi-Ting Ji, Xiao-Yan Shi, Zhou-Rui Ma, Xiao-Hua Lv, Ke Chen, Yan Chen

Article Affiliation:

Shi-Zhong Cai

Abstract:

Hematopoietic stem cells (HSCs) aging is associated with hematopoietic dysfunction and diseases. Our previous study showed that lead exposure induced a functional decline in HSCs. Allicin, a chemical extracted from the garlic (), has been reported to have anti-oxidative and anti-inflammatory effects. However, the biological activities of allicin on lead-induced toxicity, especially in the hematopoietic system, remain unclear. Here, we found that lead exposure elicited aging phenotypes in HSCs, including perturbed cell quiescence, disabled self-renewal function and colony forming ability, and myeloid-biased differentiation, all of which contributed to significant hematopoietic disorders in mice. Intragastric administration of allicin substantially ameliorated lead-induced HSCs aging phenotypeslead exposure induced a peroxide condition in HSCs leading to DNA damage, which reduced expression of the glycolytic enzyme pyruvate kinase M2 isoform (PKM2), a phenotype which was significantly ameliorated by allicin treatment. These findings suggested that allicin alleviated lead-induced HSCs aging by upregulating PKM2 expression; thus, it could be a natural herb for preventing lead toxicity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytoprotective : CK(659) : AC(385)
Problem Substances : Lead : CK(526) : AC(217)

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.