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Abstract Title:

Protective Effects of Allicin on ISO-Induced Rat Model of Myocardial Infarction via JNK Signaling Pathway.

Abstract Source:

Pharmacology. 2020 Aug 12:1-9. Epub 2020 Aug 12. PMID: 32784309

Abstract Author(s):

Wen Xu, Xiang-Peng Li, En-Ze Li, Yue-Fen Liu, Jun Zhao, Li-Na Wei, Lin Ma

Article Affiliation:

Wen Xu

Abstract:

OBJECTIVE: This research was aimed to explore protective effects of allicin on rat model of myocardial infarction via JNK signaling pathway.

METHODS: Rat myocardial ischemia model was established with subcutaneous injection of isoproterenol (ISO). Seventy-five rats were randomly divided into 5 groups (n = 15): sham group, ISO group, low-dose group (1.2 mg/kg/days for 7 days), medium-dose group (1.8 mg/kg/days for 7 days), and high-dose group (3.6 mg/kg/days for 7 days). Routine HE staining and Masson staining were performed to observe myocardial histopathology. The expression of oxidative stress-related indicators, heart tissue apoptosis-related proteins, and JNK and p-JNK proteins were measured for different groups.

RESULTS: Compared with the sham group, the T wave value of the ISO group was significantly increased (p<0.01). When allicin was administered, the T wave values at different time points in all groups were all decreased. Compared with the sham group, the ratio of eNOS, Bcl-2/Bax was significantly decreased, and p-eNOS, iNOS, caspase-3, caspase-9, and Cyt-c were significantly elevated in the ISO group (p<0.05). After allicin was administered, significant changes in these proteins were observed in the medium- and high-dose groups. There was no significant change in the expression of JNK protein in the ISO group compared with the sham group; however, the expression of eNOS and p-JNK protein were significantly upregulated (p<0.01) and the expression of p-eNOS and iNOS were significantly downregulated (p<0.01). When allicin was administered, expression of p-JNK protein was significantly downregulated.

CONCLUSION: Allicin can reduce oxidative stress damage and cardiomyocyte apoptosis in rat model of myocardial infarction and can significantly regulate JNK signaling pathway.

Study Type : Animal Study

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Sayer Ji
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