Article Publish Status: FREE
Abstract Title:

Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation.

Abstract Source:

Oncol Lett. 2016 Sep ;12(3):2232-2238. Epub 2016 Aug 25. PMID: 27602169

Abstract Author(s):

Xiaobin Chang, Jimin Zhao, Fang Tian, Yanan Jiang, Jing Lu, Junfen Ma, Xiaoyan Zhang, Guoguo Jin, Youtian Huang, Zigang Dong, Kangdong Liu, Ziming Dong

Article Affiliation:

Xiaobin Chang


Aberrant AKT and extracellular signal-regulated kinase (ERK) activation is often observed in various human cancers. Both AKT and ERK are important in the phosphoinositide 3-kinase/AKT and mitogen-activated protein kinase kinase/ERK signaling pathways, which play vital roles in cell proliferation, differentiation and survival. Compounds that are able to block these pathways have therefore a promising use in cancer treatment and prevention. The present study revealed that AKT and ERK are activated in esophageal cancer TE1 cells. Aloe-emodin, an anthraquinone present in aloe latex, can suppress TE1 cell proliferation and anchor-independent cell growth. Aloe-emodin can also reduce the number of TE1 cells in S phase. Protein analysis indicated that aloe-emodin inhibits the phosphorylation of AKT and ERK in a dose-dependent manner. Overall, the present data indicate that aloe-emodin can suppress TE1 cell growth by inhibiting AKT and ERK phosphorylation, and suggest its clinical use for cancer therapy.

Study Type : In Vitro Study

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Sayer Ji
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