Article Publish Status: FREE
Abstract Title:

α-Glucosidase Inhibitory Activity of Cycloartane-Type Triterpenes Isolated from Indonesian Stingless Bee Propolis and Their Structure-Activity Relationship.

Abstract Source:

Pharmaceuticals (Basel). 2019 Jul 1 ;12(3). Epub 2019 Jul 1. PMID: 31266160

Abstract Author(s):

Niken Pujirahayu, Debu Kumar Bhattacharjya, Toshisada Suzuki, Takeshi Katayama

Article Affiliation:

Niken Pujirahayu


This study reports on the antioxidant activity andα-glucosidase inhibitory activity of five cycloartane-type triterpenes isolated from Indonesian stingless bee (Cockerell) propolis and their structure-activity relationships. The structure of the triterpenes was determined to include mangiferolic acid (), Cycloartenol (), ambonic acid (), mangiferonic acid (), and ambolic acid (). The inhibitory test results of all isolated triterpenes againstα-glucosidase showed a high potential for inhibitory activity with an ICrange between 2.46 and 10.72µM. Among the compounds tested, mangiferonic acid (4) was the strongest α-glucosidase inhibitor with IC2.46µM compared to the standard (-)-epicatechin (1991.1 µM), and also had antioxidant activities with ICvalues of 37.74± 6.55 µM. The study on the structure-activity relationships among the compounds showed that the ketone group at C-3 and the double bonds at C-24 and C-25 are needed to increase the α-glucosidase inhibitory activity. The carboxylic group at C-26 is also more important for increasing the inhibitory activity compared with the methyl group. This study provides an approach to help consider the structural requirements of cycloartane-type triterpenes from propolis as α-glucosidase inhibitors. An understanding of these requirements is deemed necessary to find a new type of α-glucosidase inhibitor from the cycloartane-type triterpenes or to improve those inhibitors that are known to help in the treatment of diabetes.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.