Article Publish Status: FREE
Abstract Title:

Protective Effect of ALA in Crushed Optic Nerve Cat Retinal Ganglion Cells Using a New Marker RBPMS.

Abstract Source:

PLoS One. 2016 ;11(8):e0160309. Epub 2016 Aug 9. PMID: 27504635

Abstract Author(s):

Yanling Wang, Wenyao Wang, Jessica Liu, Xin Huang, Ruixing Liu, Huika Xia, Nicholas C Brecha, Mingliang Pu, Jie Gao

Article Affiliation:

Yanling Wang


In this study we first sought to determine whether RNA-binding protein with multiple splicing (RBPMS) can serve as a specific marker for cat retina ganglion cells (RGCs) using retrograde labeling and immunohistochemistry staining. RBPM was then used as an RGC marker to study RGC survival after optic nerve crush (ONC) and alpha-lipoic acid (ALA) treatment in cats. ALA treatment yielded a peak density of RBPMS-alpha cells within the peak isodensity zone (>60/mm2) which did not differ from ONC retinas. The area within the zone was significantly enlarged (control: 2.3%, ONC: 0.06%, ONC+ALA: 0.1%). As for the 10-21/mm2 zone, ALA treatment resulted in a significant increase in area (control: 34.5%, ONC: 12.1%, ONC+ALA: 35.9%). ALA can alleviate crush-induced RGC injury.

Study Type : In Vitro Study

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