Article Publish Status: FREE
Abstract Title:

Effects of Alpha-Lipoic Acid Supplementation on Cardiovascular Disease Risk Factors inβ-Thalassemia Major Patients: A Clinical Trial Crossover Study.

Abstract Source:

J Blood Med. 2020 ;11:131-139. Epub 2020 May 7. PMID: 32494211

Abstract Author(s):

Khadijeh Jamshidi, Hadi Abdollahzad, Mostafa Nachvak, Mansour Rezaei, Mohammad Reza Golpayegani, Elham Sharifi Zahabi

Article Affiliation:

Khadijeh Jamshidi


Aim: Thalassemia is one of the most common genetic diseases, andcardiovascular disease (CVD) has been considered as the leading cause of mortality in more than 50% of β-thalassemia patients. The aim of this study was to determine the effects of alpha-lipoic acid (ALA) on CVD risk factors in β-thalassemia major patients.

Methods: Twentyβ-thalassemia major patients participated in this randomized crossover clinical trial study. Participants were randomly assigned to ALA (600 mg/day) or placebo groups for two 8-wk interventions that were separated by a 3-wk washout period. The CVD risk factors including serum osteoprotegerin (OPG),homocysteine, lipoprotein-associated phospholipase Aand trimethylamine-oxide were measured at the beginning and the end of each intervention phase according to the standard protocol.

Results: Serum OPG reduced significantly in the ALA group in all participants (5.38± 2.79 to 3.27 ± 2.43 ng/mL,= .003) and in the male subgroup (5.24± 2.56 to 3.13 ± 2.5 ng/mL,= .015); this reduction was significant in comparison with the placebo group (= .013). The changes in other CVD risk factors were not significant.

Conclusion: The results of this study showed that after 8-wk of ALA consumption, the serum OPG reduced significantly inβ-thalassemia major patients. Therefore, controlling the serum OPG level with ALA consumption can be an important complementary therapeutic option to prevent the progression of CVD in β-thalassemia major patients.

Study Type : Human Study

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