Abstract Title:

Antioxidant and anti-inflammatory properties of alpha lipoic acid protect against valproic acid induced liver injury.

Abstract Source:

Can J Physiol Pharmacol. 2020 Dec 4. Epub 2020 Dec 4. PMID: 33275538

Abstract Author(s):

Marwa Abdeltawab Mohammed, Doaa Mostafa Gharib, Hoda Ramadan Reyad, Alaa Aboud Mohamed, Fadwa A Elroby, Hoda Sayed Mahmoud

Article Affiliation:

Marwa Abdeltawab Mohammed


: Valproic acid (VPA) is one of the most used anti-epileptic drugs inspite of its many adverse effects as anemia, leucopenia, thrombocytopenia, and liver toxicity. The hepatoprotective effect of alpha-lipoic acid (ALA) was confirmed.

AIM OF THE STUDY: The aim of this study was to detect the protective effect of ALA against the adverse effects of VPA. Materials&Methods: Thirty white albino Wistar male rats were divided into 4 groups. Group (1) was the control group; Group (2) included rats that received ALA (100mg/kg/day) orally for 14 days; Group (3) and Group (4) included rats that received VPA (500 mg/kg/day) for 15 days intraperitoneal, but group 4 rats received ALA (100mg/kg/day) orally for 14 days prior to VPA. Blood samples were collected and livers were excised from rats for colorimetric analysis and rt-PCR.

RESULTS: Rats that received VPA showed leucopenia, thrombocytopenia, a significant decrease of SOD, glutathione, Nrf2, and Sirt1, besides a significant increase of MDA and TNF alpha. Prior treatment with ALA prevented all these results.

CONCLUSION: ALA protected against VPA-induced liver damage and hematological disturbance via anti-oxidant and anti-inflammatory properties.

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