n/a
Article Publish Status: FREE
Abstract Title:

α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice.

Abstract Source:

Aging (Albany NY). 2019 Dec 6 ;11(23):11084-11110. Epub 2019 Dec 6. PMID: 31806859

Abstract Author(s):

Dan Li, Qianyu Liu, Xiuqiang Lu, Zhengqiu Li, Chunming Wang, Chung-Hang Leung, Yitao Wang, Cheng Peng, Ligen Lin

Article Affiliation:

Dan Li

Abstract:

Low-grade chronic adipose tissue inflammation contributes to the onset and development of aging-related insulin resistance and type 2 diabetes. In the current study,α-mangostin, a xanthone isolated from mangosteen (), was identified to ameliorate lipopolysaccharides-induced acute adipose tissue inflammation in mice, by reducing the expression of pro-inflammatory cytokines and chemokines. In a cohort of young (3 months) and old (18-20 months) mice,α-mangostin mitigated aging-associated adiposity, hyperlipidemia, and insulin resistance. Further study showed that α-mangostin alleviated aging-related adipose tissue inflammation by reducing macrophage content and shifting pro-inflammatory macrophage polarization. Moreover, α-mangostin protected the old mice against liver injury through suppressing the secretion of microRNA-155-5p from macrophages. The above results demonstrated that α-mangostin represents a new scaffold to alleviate adipose tissue inflammation, which might be a novel candidate to treat aging-related metabolic disorders.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.