Article Publish Status: FREE
Abstract Title:

Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol.

Abstract Source:

Oxid Med Cell Longev. 2019 ;2019:8419810. Epub 2019 Oct 21. PMID: 31772712

Abstract Author(s):

Tayana Silva de Carvalho, Patrick Bruno Cardoso, Mateus Santos-Silva, Sávio Lima-Bastos, Waldo Lucas Luz, Nadyme Assad, Nayara Kauffmann, Adelaide Passos, Alódia Brasil, Carlomagno Pacheco Bahia, Suellen Moraes, Amauri Gouveia, Evander de Jesus Oliveira Batista, Karen Renata Matos Herculano Oliveira, Anderson Manoel Herculano

Article Affiliation:

Tayana Silva de Carvalho


Anxiety is a common symptom associated with high caffeine intake. Although the neurochemical mechanisms of caffeine-induced anxiety remain unclear, there are some evidences suggesting participation of oxidative stress. Based on these evidences, the current study is aimed at evaluating the possible protective effect of alpha-tocopherol (TPH) against anxiety-like behavior induced by caffeine (CAF) in zebrafish. Adult animals were treated with CAF (100 mg/kg) or TPH (1 mg/kg)+CAF before behavioral and biochemical evaluations. Oxidative stress in the zebrafish brain was evaluated by a lipid peroxidation assay, and anxiety-like behavior was monitored using light/dark preference and novel tank diving test. Caffeine treatment evoked significant elevation of brain MDA levels in the zebrafish brain, and TPH treatment prevented this increase. Caffeine treatment also induced anxiety-like behavior, while this effect was not observed in the TPH+CAF group. Taken together, the current study suggests that TPH treatment is able to inhibit oxidative stress and anxiety-like behavior evoked by caffeine.

Study Type : Animal Study

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