Abstract Title:

Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain.

Abstract Source:

J Neuroimmunol. 2006 Jul ;176(1-2):16-23. Epub 2006 May 11. PMID: 16697052

Abstract Author(s):

Angelica Becaria, Debomoy K Lahiri, Stephen C Bondy, DeMao Chen, Ali Hamadeh, Huihui Li, Russell Taylor, Arezoo Campbell

Article Affiliation:

Angelica Becaria


Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (Abeta) peptides. The present study was designed to evaluate the effect of a 3-month exposure of mice to copper sulfate (8 microM), aluminum lactate (10 or 100 microM), or a combination of the salts. Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels.

Study Type : Animal Study

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