Abstract Title:

Ambient air pollutants are associated with newly diagnosed tuberculosis: A time-series study in Chengdu, China.

Abstract Source:

Sci Total Environ. 2018 Aug 1 ;631-632:47-55. Epub 2018 Mar 7. PMID: 29524902

Abstract Author(s):

Sui Zhu, Lan Xia, Jianlin Wu, Shaobing Chen, Fei Chen, Fangfang Zeng, Xiuwei Chen, Chuang Chen, Yong Xia, Xing Zhao, Juying Zhang

Article Affiliation:

Sui Zhu


Although a few studies have analyzed the associations between ambient air pollutants and the development of tuberculosis (TB), most have been conducted in the core countries with inconsistent results. In this study, we used a distributed lag non-linear model to investigate the associations between the newly diagnosed TB cases and daily exposure to particulate matter with an aerodynamic diameter of<10μm (PM), nitrogen dioxide (NO), and sulfur dioxide (SO) in Chengdu, a severely polluted city. There were 36,108 newly diagnosed active TB cases from January 1, 2010 to December 31, 2015 in Chengdu. In a single-pollutant model, the cumulative relative risk of active TB cases was 1.06 [lag of 0 to 21days, 95% confidence interval (CI): 1.01-1.11] for each 10μg/mincrease in PMabove the threshold of 70μg/m; 1.06 (lag of 0 to 2days, 95% CI: 1.03-1.09) for each 10μg/mincrease in NOabove the threshold of 40μg/m; and 1.07 (lag of 0 to 2days, 95% CI: 1.02-1.12) for each 10μg/mincrease in SOabove the threshold of 60μg/m. Meanwhile, we found a positive association in males after exposure to a 10μg/mincrease in SOabove the threshold of 60μg/mat a lag of 0 to 2days. Exposure to PM, NO, and SOwas associated with an increment in the incidence of active TB cases.

Study Type : Human Study

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