Air pollution, lung function and COPD: results from the population-based UK Biobank study.
Eur Respir J. 2019 Jul 8. Epub 2019 Jul 8. PMID: 31285306
Ambient air pollution increases the risk of respiratory mortality but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors.We used UK Biobank data on 3 03 887 individuals aged 40-69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of Land Use Regression-based estimates of particulate matter (PM, PMand PM) and nitrogen dioxide (NO) concentrations with forced expiratory volume in 1 s (FEV), forced vital capacity (FVC), the FEV/FVC ratio, and COPD (FEV/FVC