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Article Publish Status: FREE
Abstract Title:

Ameliorative effect of black ginseng extract against oxidative stress-induced cellular damages in mouse hepatocytes.

Abstract Source:

J Ginseng Res. 2019 Apr ;43(2):179-185. Epub 2017 Oct 21. PMID: 30976158

Abstract Author(s):

Qaisra Naheed Choudhry, Jun Ho Kim, Hyung Taek Cho, Wan Heo, Jeong-Jun Lee, Jin Hyup Lee, Young Jun Kim

Article Affiliation:

Qaisra Naheed Choudhry

Abstract:

Background: Oxidative stress induces the production of reactive oxygen species (ROS), which play important causative roles in various pathological conditions. Black ginseng (BG), a type of steam-processed ginseng, has drawn significant attention due to its biological activity, and is more potent than white ginseng (WG) or red ginseng (RG).

Methods: We evaluated the protective effects of BG extract (BGE) against oxidative stress-induced cellular damage, in comparison with WG extract (WGE) and RG extract (RGE) in a cell culture model. Ethanolic extracts of WG, RG, and BG were used to evaluate ginsenoside profiles, total polyphenols, flavonoid contents, and antioxidant activity. Using AML-12 cells treated with HO, the protective effects of WGE, RGE, and BGE on cellular redox status, DNA, protein, lipid damage, and apoptosis levels were investigated.

Results: BGE exhibited significantly enhanced antioxidant potential, as well as total flavonoid and polyphenol contents. ATP levels were significantly higher in BGE-treated cells than in control; ROS generation and glutathione disulfide levels were lower but glutathione (GSH) and NADPH levels were higher in BGE-treated cells than in other groups. Pretreatment with BGE inhibited apoptosis and therefore protected cells from oxidative stress-induced cellular damage, probably through ROS scavenging.

Conclusion: Collectively, our results demonstrate that BGE protects AML-12 cells from oxidative stress-induced cellular damages more effectively than WGE or RGE, through ROS scavenging, maintenance of redox status, and activation of the antioxidant defense system.

Study Type : In Vitro Study

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