Abstract Title:

Ameliorative effects of Spirulina maxima and Allium sativum on lead acetate-induced testicular injury in male albino rats with respect to caspase-3 gene expression.

Abstract Source:

Acta Histochem. 2019 Feb ;121(2):198-206. Epub 2018 Dec 24. PMID: 30587387

Abstract Author(s):

Mohamed I Abdrabou, Ebtihal M M Elleithy, Noha A E Yasin, Youssef M Shaheen, Mona Galal

Article Affiliation:

Mohamed I Abdrabou


The present study was conducted to evaluate the ameliorative effects of Allium sativum (garlic) as well as Spirulina maxima on lead acetate toxicity in rat testes. Forty adult, male, albino rats were divided into four groups (10 rats/each): group I served as the control; group II contained rats that received lead acetate (100 mg/kg); group III contained rats that received both lead acetate (100 mg/kg) and garlic (600 mg/kg); and group IV contained rats that received both lead acetate (100 mg/kg) and spirulina (500 mg/kg). All treatments were performed daily for one month. Serum testosterone levels, oxidative stress parameters, expression of the caspase-3 gene and histological, histo-morphometric and ultrastructure alterations in the testes were investigated. The results revealed that the Pb-treated group exhibited a significant increase in MDA concentration concomitantly with a decrease in serum testosterone levels, antioxidative marker levels and caspase-3 gene expression. Several histological and histo-morphometric alterations were observed in this group. Co-administration with spirulina or garlic caused a significant increase in testosterone levels, testicular SOD and CAT activities, and caspase-3 gene expression and a decrease in MDA levels, with improvement in histological and histo-morphometric alterations. These results suggested that spirulina was more effective at providing protection against Pb-induced reproductive damage in rats than garlic, indicating the beneficial role of spirulina in improvement of spermatogenesis and steroidogenesis after lead exposure.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.