Article Publish Status: FREE
Abstract Title:

Analytical Profile and Antioxidant and Anti-Inflammatory Activities of the Enriched Polyphenol Fractions Isolated from Bergamot Fruit and Leave.

Abstract Source:

Antioxidants (Basel). 2021 Jan 20 ;10(2). Epub 2021 Jan 20. PMID: 33498213

Abstract Author(s):

Giovanna Baron, Alessandra Altomare, Marco Mol, Jessica Leite Garcia, Camila Correa, Angela Raucci, Luigi Mancinelli, Sarah Mazzotta, Laura Fumagalli, Giuseppe Trunfio, Luigi Tucci, Elena Lombardo, Domenico Malara, Elzbieta Janda, Vincenzo Mollace, Marina Carini, Ezio Bombardelli, Giancarlo Aldini

Article Affiliation:

Giovanna Baron


The aim of the study is to compare the qualitative and semi-quantitative profile of the polyphenol fraction purified from the leaf (BLPF) and fruit (BFPF) of bergamot (), and to evaluate their antioxidant and anti-inflammatory activity. The analytical qualitative profile was carried out by LC-ESI/MS using three different approaches: targeted (searching analytes already reported in bergamot extract), semi-targeted (a selective search of 3-hydroxy-3-methylglutarate [HMG] derivatives involved in the cholesterol reducing activity of BPF) and untargeted. A total number of 108 compounds were identified by using the three approaches, 100 of which are present in both the extracts thus demonstrating a good qualitative overlapping of polyphenols between the two extracts. The antioxidant activity was higher for BLPF in respect to BFPF but when normalized in respect to the polyphenol content they were almost overlapping. Both the extracts were found to dose dependently inhibit cell inflammation stimulated with IL-1α. In conclusion, the comparison of the qualitative and quantitative profile of polyphenols as well as of the antioxidant and anti-inflammatory activity of bergamot leaf and fruit well indicates that leaf is a valid source of bergamot polyphenol extraction and an even richer source of polyphenol in respect to the fruit.

Study Type : In Vitro Study

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