Abstract Title:

Drug-induced pruritic micropapular eruption: anastrozole, a commonly used aromatase inhibitor.

Abstract Source:

Dermatol Online J. 2009;15(7):14. Epub 2009 Jul 15. PMID: 19903442

Abstract Author(s):

Tomi Bremec, Jasmina Demsar, Bostjan Luzar, Milos D Pavlović


Anastrozole, a selective nonsteroidal aromatase inhibitor is widely used as an adjuvant therapy for postmenopausal women with early hormone-sensitive breast cancer. There are few reports on cutaneous side effects of anastrozole. It may induce subacute cutaneous lupus erythematosus, erythema nodosum, cutaneous vasculitis, and nondescript skin eruptions. A 68-year-old woman was prescribed anastrozole after surgical removal of her breast cancer and adjuvant radiation therapy. Two months later she experienced a generalized pruritic micropapular eruption. History, clinical presentation, histology and inadvertent re-exposure to the drug confirmed that anastrozole triggered the exanthem. Pruritic micropapular eruption is a typical pattern for a drug hypersensitivity reaction. Anastrozole should be added to the list of medications able to induce not only non-specific eruptions but the type of exanthem typically triggered by drugs.

Study Type : Human Study

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Sayer Ji
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