Andrographis contains compounds which have antiprotozoal activity. - GreenMedInfo Summary
In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata.
Phytother Res. 2009 Jan;23(1):126-8. PMID: 18683849
National Institute of Malaria Research, Field Unit, Sector III, BHEL, Hardwar 249 403, India. email@example.com
Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 microg/ml and 8 microg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product.