Article Publish Status: FREE
Abstract Title:

Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.

Abstract Source:

Funct Neurol. 2016 Jan-Mar;31(1):53-60. PMID: 27027895

Abstract Author(s):

Rosaria Greco, Francesca Siani, Chiara Demartini, Annamaria Zanaboni, Giuseppe Nappi, Sergio Davinelli, Giovanni Scapagnini, Cristina Tassorelli

Article Affiliation:

Rosaria Greco


Administration of nitroglycerin (NTG) to rats induces a hyperalgesic condition and neuronal activation of central structures involved in migraine pain. In order to identify therapeutic strategies for migraine pain, we evaluated the anti-nociceptive activity of Andrographis Paniculata (AP), a herbaceous plant, in the hyperalgesia induced by NTG administration in the formalin test. We also analyzed mRNA expression of cytokines in specific brain areas after AP treatment. Male Sprague-Dawley rats were pre-treated with AP extract 30 minutes before NTG or vehicle injection. The data show that AP extract significantly reduced NTG-induced hyperalgesia in phase II of the test, 4 hours after NTG injection. In addition, AP extract reduced IL-6 mRNA expression in the medulla and mesencephalon and also mRNA levels of TNFalpha in the mesencephalic region. These findings suggest that AP extract may be a potential therapeutic approach in the treatment of general pain, and possibly of migraine.

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