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Abstract Title:

Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice.

Abstract Source:

Int Immunopharmacol. 2021 Jul ;96:107808. Epub 2021 May 30. PMID: 34162168

Abstract Author(s):

Jiawei Zhang, Yaling Zheng, Yao Zhao, Yaxuan Zhang, Yu Liu, Fang Ma, Xiuzhe Wang, Jianliang Fu

Article Affiliation:

Jiawei Zhang

Abstract:

Alzheimer's disease is a devastating neurodegenerative disorder, with no disease-modifying treatment available yet. There is increasing evidence that neuroinflammation plays a critical role in the pathogenesis of AD. Andrographolide (Andro), a labdane diterpene extracted from the herb Andrographis paniculata, has been reported to exhibit neuroprotective property in central nervous system diseases. However, its effects on Aβ and Aβ-induced neuroinflammation have not yet been studied. In the present study, we found that Andro administration significantly alleviated cognitive impairments, reduced amyloid-β deposition, inhibited microglial activation, and decreased the secretion of proinflammatory factors in APP/PS1 mice. Furthermore, transcriptome sequencing analysis revealed that Andro could significantly decrease the expression of Itgax, TLR2, CD14, CCL3, CCL4, TLR1, and C3ar1 in APP/PS1 mice, which was further validated by qRT-PCR. Our results suggest that Andro might be a potential therapeutic drug for AD by regulating neuroinflammation.

Study Type : Transgenic Animal Study

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