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Abstract Title:

Andrographolide, a novel inducer of apelin gene expression.

Abstract Source:

J Ethnopharmacol. 2021 Aug 3 ;280:114487. Epub 2021 Aug 3. PMID: 34352330

Abstract Author(s):

R Alipanah-Moghadam, A Mehri, F Manafi, V Malekzadeh, A Nemati, V Aghamohammadi, M Mazani, C T Clark Cain, M Mohammadzadeh-Vardin

Article Affiliation:

R Alipanah-Moghadam

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata (A. paniculata) has been used as a traditional medicine in Asia and Scandinavia for centuries to remedy several illnesses. It has since been shown to possess antibacterial, antifungal, antiviral, anti-neoplasm, hepatoprotective, hypoglycemic, hypocholesterolemic, and energetic effects.

AIMS OF THE STUDY: This study sought to investigate the effect of Andrographolide on apelin gene expression and serum levels of glucose.

MATERIALS AND METHODS: In this study, 18 male rats were used. They were divided into three groups of six, including i) negative control group, ii) 3.5 mg/kg Andrographolide group, and iii) 7 mg/kg Andrographolide group. Apelin gene expression was investigated by real-time PCR method. Serum levels of glucose were measured by the photometric method.

RESULTS: The results of this study revealed that 3.5 and 7 mg doses per kg of body weight of andrographolide, for six days, significantly increased hepatic expression of apelin gene in male Wistar rats, as compared with the control group (p < 0.05). Serum levels of glucose at doses of 3.5 and 7 mg/kg of andrographolide, and in the control group, were 71.5 ± 8.96, 51.5 ± 2.64, and 93.87 ± 14.27 mg/dl, respectively. Andrographolide induced a decrease in serum levels of HDL-c and an increase in LDL-c/HDL-c ratio.

CONCLUSIONS: Our results suggest that Andrographolide can elicit an increase of hepatic apelin gene expression and a decrease in serum levels of blood glucose.

Study Type : Animal Study

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