Annona muricata as possible alternative in the treatment of hyperglycemia. - GreenMedInfo Summary
as Possible Alternative in the Treatment of Hyperglycemia: A Systematic Review.
J Med Food. 2022 Jan 24. Epub 2022 Jan 24. PMID: 35076315
Patricia Martín Del Campo-Rayas
The study of the bioactive compounds present inextracts has won popularity due to the growing evidence of its medicinal properties, including anticancer and antidiabetic effects. The aim of this study was to systematically analyze the scientific evidence regardings hypoglycemic effect and the factors affecting the composition of bioactive compounds in different extracts,, andstudies were analyzed in the PubMed database following the strategies proposed by the PRISMA guidelines. It was identified that the methodology and results of the articles were heterogeneous. The hypoglycemic function was found to be mediated by multiple effects at the molecular level, including enzymatic inhibition, pancreaticcells proliferation stimulation, and food intake-related genes regulation. These effects depend on several factors such as plant bioactive compounds content, extraction method, and characteristics of the organism that consumes it. Therefore, this review exhibits the necessity of further research, using established doses according to the bioactive compounds content in.