Article Publish Status: FREE
Abstract Title:

Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention.

Abstract Source:

Mol Nutr Food Res. 2013 Nov ;57(11):1908-17. Epub 2013 Jun 19. PMID: 23784800

Abstract Author(s):

Soyoung Lim, Jianteng Xu, Jaeyong Kim, Tzu-Yu Chen, Xiaoyu Su, Joseph Standard, Edward Carey, Jason Griffin, Betty Herndon, Benjamin Katz, John Tomich, Weiqun Wang

Article Affiliation:

Soyoung Lim


SCOPE: Anthocyanins, the natural pigments in plant foods, have been associated with cancer prevention. However, the content of anthocyanins in staple foods is typically low and the mechanisms by which they exert anticancer activity is not yet fully defined.

METHODS AND RESULTS: We selected an anthocyanin-enriched purple-fleshed sweet potato clone, P40, and investigated its potential anticancer effect in both in vitro cell culture and in vivo animal model. In addition to a high level of total phenolics and antioxidant capacity, P40 possesses a high content of anthocyanins at 7.5 mg/g dry matter. Treatment of human colonic SW480 cancer cells with P40 anthocyanin extracts at 0-40μM of peonidin-3-glucoside equivalent resulted in a dose-dependent decrease in cell number due to cytostatic arrest of cell cycle at G1 phase but not cytotoxicity. Furthermore, dietary P40 at 10-30% significantly suppressed azoxymethane-induced formation of aberrant crypt foci in the colons of CF-1mice in conjunction with, at least in part, a lesser proliferative PCNA and a greater apoptotic caspase-3 expression in the colon mucosal epithelial cells.

CONCLUSION: These observations, coupled with both in vitro and in vivo studies reported here, suggest anthocyanin-enriched sweet potato P40 may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms.

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