Anti-aging effects of Korean red ginseng. - GreenMedInfo Summary

Background: The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in the body, and its disruption has been associated with aging. The differentiated embryo chondrocyte () gene is related to circadian rhythm. To our knowledge, there are no reports of the relationship between dec gene expression and KRG effect. Therefore, we treatedgene knockout (KO) aging mice with KRG to study anti-aging related effects and possible mechanisms.

Methods: We evaluated KRG and expression ofgenes in an ototoxicity model.genes expression in livers of aging mice was further analyzed. Then, we assessed the effects of DEC KO on hearing function in mice by ABR. Finally, we performed DNA microarray to identify KRG-related gene expression changes in mouse liver and assessed the results using KEGG analysis.

Results: KRG decreased the expression ofgenes in ototoxicity model, which may contribute to its anti-aging efficacy. Moreover, KRG suppressedgenes expression in liver of wild type indicating inhibition of senescence. ABR test indicated that KRG improved auditory function in aging mouse, demonstrating KRG efficacy on aging related diseases.

Conclusion: Finally, in KEGG analysis of 238 genes that were activated and 158 that were inhibited by KRG in DEC KO mice, activated genes were involved in proliferation signaling, mineral absorption, and PPAR signaling whereas the inhibited genes were involved in arachidonic acid metabolism and peroxisomes. Our data indicate that inhibition of senescence-relatedgenes may explain the anti-aging efficacy of KRG.