Article Publish Status: FREE
Abstract Title:

Anti-aging Effects of Mangosteen Peel Extract and Its Phytochemical Compounds: Antioxidant Activity, Enzyme Inhibition and Molecular Docking Simulation.

Abstract Source:

Trop Life Sci Res. 2020 Oct ;31(3):127-144. Epub 2020 Oct 15. PMID: 33214860

Abstract Author(s):

Wahyu Widowati, Chrismis Novalina Ginting, I Nyoman Ehrich Lister, Ermi Girsang, Annisa Amalia, Satrio Haryo Benowo Wibowo, Hanna Sari Widya Kusuma, Rizal

Article Affiliation:

Wahyu Widowati


Skin aging is a complex natural process characterised by gradual diminishment of structural integrity and physiological imbalance of the skin tissue. Since the oxidative stress is tightly corelated to the skin aging process, the usage of antioxidant may serve as favourable strategies for slowing down the skin aging process. Mangosteen is an important fruit commodity and its extract had been extensively studied and revealing various biological activities. Present study aimed to assess the antioxidant and antiaging activity of mangosteen peel extract (MPE) and its phytochemical compounds. MPE and its compounds were subjected to ferric reducing antioxidant power (FRAP), hydroperoxide (HO) scavenging, anti-collagenase, anti-elastase, anti-hyaluronidase and anti-tyrosinase assay. MPE has the highest FRAP 116.31± 0.60 μM Fe(II) μgextract, ICof MPE on HOscavenging activity was 54.61μg mL. MPE also has the highest anti elastase activity at IC7.40μg mL. Alpha-mangostin showed potent anti-collagenase activity (IC9.75μg mL). While gamma-mangostin showed potent anti-hyaluronidase (IC23.85μg mL) and anti-tyrosinase (IC50.35μg mL). MPE and its compounds were evaluatedfor antioxidant and antiaging activities. Current findings may provide scientific evidence for possible usage of mangosteen extract and its compounds as antioxidant and antiaging agent.

Study Type : In Vitro Study

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